肿瘤预防与治疗2026，Vol.39Issue(9)：799-805,7.DOI:10.3969/j.issn.1674-0904.2026.09.010
胃腺癌伴神经内分泌分化的研究进展
Research Progress on Gastric Adenocarcinoma with Neuroendocrine Dif-ferentiation
摘要
Abstract
Gastric cancer is one of the most common malignancies of the digestive system and exhibits marked biological heterogeneity.Among gastric cancers,the vast majority are gastric adenocarcinomas,which represent the predominant histo-logical type in gastric cancer research and clinical practice.With advances in immunohistochemistry and molecular patholo-gy,"hidden"neuroendocrine differentiation in gastric adenocarcinoma has received increasing attention and is considered to represent a distinct pathological phenotype,namely gastric adenocarcinoma with neuroendocrine differentiation(GC-NED).While retaining the basic histological features of adenocarcinoma,this phenotype can express neuroendocrine markers such as synaptophysin and chromogranin A,and may be associated with greater invasiveness,poorer prognosis,and differences in treatment response.In recent years,studies on its pathological diagnosis,clinicopathological characteristics,prognostic val-ue,and therapeutic strategies have increased,but its diagnostic criteria and clinical significance remain inconclusive.This review systematically summarizes the research progress on GC-NED and discusses its potential clinical value and future per-spectives.关键词
胃腺癌/神经内分泌分化/病理特征/临床预后/治疗策略/文献综述Key words
Adenocarcinoma/Neuroendocrine differentia-tion/Pathological features/Clinical prognosis/Treatment strategies/Literature review分类
医药卫生引用本文复制引用
肖鹂瑶,李蓉,詹晨阳,潜均仪,胡凤娣..胃腺癌伴神经内分泌分化的研究进展[J].肿瘤预防与治疗,2026,39(9):799-805,7.基金项目
This study was supported by grants from Yunnan Cancer Hospital(No.CZ01972024B3)and Kunming Medical University(No.QL-JBGS-09). 云南省肿瘤医院消化内科省级临床重点专科建设项目(编号:CZ01972024B3) （No.CZ01972024B3）
昆明医科大学领研临床科研项目(编号:QL-JBGS-09) （编号:QL-JBGS-09）
