药学研究2026，Vol.45Issue(8)：870-874,5.DOI:10.13506/j.cnki.jpr.2026.08.004
壳聚糖凝胶的制备、体外释放度及抑菌性能
Study of preparation,in vitro release and antibacterial activity of chitosan gel
摘要
Abstract
Objective To prepare chitosan antibacterial gel and conduct a comprehensive quality study of chitosan gels and to ensure the quality and safety of chitosan-related product,establish the detection method of chitosan content in chitosan gel and evaluate its bacteriostasis.Methods The chitosan content of PVA-chitosan gel was indirectly detected by acid hydrolysis and HPLC determination of glucosamine.The release curve of chitosan in chitosan gel was determined by gel dissolution method and the corresponding release model was established.The bacteriostatic activity of chitosan antimicrobial gel was investigated by the inhibition zone method.Results The detection of chitosan in chitosan gel by acid hydrolysis combined HPLC determination has high accuracy.The average recovery rate of chitosan detection in the sample was 98.51%,with an RSD value of 2.37%.The release of chitosan gel conforms to the Ritger Peppas kinetic equation and the release mechanism conforms to Fick diffusion.Chitosan gel has good antibacterial activity,reaching medium sensitive strength.Conclusion The established HPLC assay was easy to operate and the results were reliable;The chitosan gel possessed slow-release characteristics and excellent antimicrobial activity.关键词
壳聚糖凝胶/体外释放度/抑菌活性Key words
Chitosan gel/In vitro release degree/Bacteriostatic activity分类
医药卫生引用本文复制引用
崔婧,卢欢,耿春辉,张荣庭,王哲..壳聚糖凝胶的制备、体外释放度及抑菌性能[J].药学研究,2026,45(8):870-874,5.基金项目
河北省药品监督管理局科技计划项目(No.2023ZC1028) （No.2023ZC1028）
