摘要
Abstract
Ginseng is a precious traditional Chinese herbal medicine,possessing significant nutritional value and extensive health benefits.Ginsenosides,as the primary active constituents of ginseng,exhibit various pharmacological activities such as antitumor effects,nervous system regulation,cardiovascular protection,and immune enhancement.Their mechanisms of action involve the regulation of multiple key signaling pathways,demonstrating significant potential for drug development.However,traditional production methods relying on plant extraction are limited by resource scarcity,long growth cycles,and low ginsenoside content,making it difficult to meet growing research and market demands.Synthetic biology offers an innovative solution for sustainable and efficient production of ginsenosides by elucidating and reconstructing their biosynthetic pathways in heterologous hosts such as microbes.This article reviews the recent research advances in pharmacological activities,mechanisms of action,and synthetic biology of ginsenosides.Additionally,it discusses the prospects of applying synthetic biology in the green manufacturing of ginsenosides,aiming to provide insights for future innovative drug development.关键词
人参/人参皂苷/药理活性/合成生物学/绿色制造Key words
Panax ginseng/Ginsenoside/Pharmacological activity/Synthetic biology/Green manufacturing分类
医药卫生
