陕西中医2026，Vol.47Issue(9)：1207-1211,5.DOI:10.3969/j.issn.1000-7369.2026.09.009
加味四妙散治疗宫颈炎伴HPV感染的疗效及对患者阴道微生态、远期预后的影响
Effect of Jiawei Simiao powder on cervicitis associated with HPV infection and its influence on vaginal microecology and long-term prognosis
摘要
Abstract
Objective:To analyze the curative effect of Jiawei Simiao powder on cervicitis associated with human papillomavirus(HPV)infection and its influence on vaginal microecology and long-term prognosis.Methods:A total of 120 patients with cervicitis complicated by HPV infection were selected and divided into a control group and an ob-servation group,with 60 cases in each group.The control group was treated with human interferon α-2b vaginal effer-vescent tablets,the observation group based on this,and with Jiawei Simiao powder treatment.The cleanliness of va-ginal discharge,vaginal discharge volume,scab stopping time,and wound healing time of patients in the two groups were recorded.Serum interleukin-6(IL-6),interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),vaginal microeco-logical indicators(diversity of bacterial flora,density of bacterial flora,vaginal pH value)were detected before and af-ter treatment.The total effective rate,HPV negative conversion rate and adverse reactions were compared between the two groups after 6 months of follow-up.Results:Compared with the control group,the vaginal secretion cleanli-ness and vaginal discharge volume of the observation group were lower,scab stopping bleeding time and wound heal-ing time were shorter(P＜0.05).Compared with the control group,the levels of IL-6,TNF-α in the observation group after treatment were lower,and the level of IFN-γ was higher,the differences were significant(P＜0.05).Compared with the control group,the diversity and density of microflora in the observation group were better after treatment,and the vaginal pH value was smaller,with significant differences(P＜0.05).Compared with the control group,the total effective rate and HPV negative conversion rate of the observation group were higher,the differences were significant(P＜0.05).No difference was observed in adverse reactions between the two groups(P＞0.05).Conclusion:Jiawei Simiao powder in the treatment of cervicitis with HPV infection can further improve the curative effect,help to improve the vaginal microecology and long-term prognosis,and has a certain clinical promotion value.关键词
宫颈炎/人乳头瘤病毒/加味四妙散/人干扰素α-2b阴道泡腾片/阴道微生态/远期预后Key words
Cervicitis/Human papillomavirus/Jiawei Simiao powder/Recombinant human interferon α-2b va-ginal effervescent tablets/Vaginal microecology/Long term prognosis分类
医药卫生引用本文复制引用
谢静,仲丽平..加味四妙散治疗宫颈炎伴HPV感染的疗效及对患者阴道微生态、远期预后的影响[J].陕西中医,2026,47(9):1207-1211,5.基金项目
江苏省中医药和中西医结合科研项目(ZXFZ026094) （ZXFZ026094）
