有色金属材料与工程2026，Vol.47Issue(3)：28-38,11.DOI:10.13258/j.cnki.nmme.20260330001
多功能纳米材料在声动力治疗领域的研究进展
Recent advances in multifunctional nanomaterials for sonodynamic therapy
摘要
Abstract
Sonodynamic therapy(SDT)is an emerging non-invasive treatment modality that uses low-intensity ultrasound to activate sonosensitizers,generating sonochemical and sonomechanical effects for the eradication of tumor cells or bacteria.Owing to its advantages,including deep tissue penetration,high precision,low toxicity,minimal tissue damage,and the ability to induce immunogenic cell death,SDT is more suitable for treating deep-seated tissues than photodynamic therapy and holds broad application prospects in the biomedical field.However,the therapeutic efficacy of SDT is often constrained by the complex tumor microenvironment,lack of specific targeting in drug delivery,and suboptimal sonosensitization performance.Therefore,addressing these challenges through the design and functional modification of sonosensitizers is critical for developing strategies to enhance SDT efficiency.This review summarizes the currently recognized mechanisms of SDT and provided an overview of various strategies based on multifunctional nanomaterials to improve SDT efficacy from three perspectives:modulating the TME,optimizing targeted delivery,and enhancing sonosensitization performance.In addition,the challenges and limitations in the current development of SDT are discussed.关键词
声动力治疗/肿瘤微环境/靶向运输/声敏性能/多功能纳米材料Key words
sonodynamic therapy/tumor microenvironment/targeted delivery/sonosensitization performance/multifunctional nanomaterials分类
通用工业技术引用本文复制引用
涂洁,欧阳瑞镯..多功能纳米材料在声动力治疗领域的研究进展[J].有色金属材料与工程,2026,47(3):28-38,11.基金项目
中国五矿集团有限公司科技专项计划项目(2022ZXA02) （2022ZXA02）
