有色金属材料与工程2026，Vol.47Issue(3)：39-48,10.DOI:10.13258/j.cnki.nmme.20260413001
镁掺杂微弧氧化TiO2多孔涂层的制备及其生物学性能研究
Preparation and biological properties of Mg-doped porous TiO2 coatings by micro-arc oxidation
摘要
Abstract
To address the clinical challenges of poor interfacial integration and high infection risk associated with pacemaker fixation hooks,magnesium-doped porous TiO2 coatings were prepared on pure titanium surfaces via micro-arc oxidation.The results indicate that appropriate magnesium doping did not alter the anatase phase but significantly homogenized the porous topological morphology,leading to a substantial improvement in hydrophilicity(with the contact angle reduced to 31.2°).The modified coatings exhibite potent broad-spectrum antibacterial activity(inhibition rate>90%).Notably,the TiO2-Mg2 group demonstrate the optimal comprehensive performance:a hemolysis rate of only 1.30%,a free radical scavenging rate of 86.2%,and a cell viability of 95.5%,while significantly promoting the spreading of cardiomyocytes.Through synergistic physical-chemical regulation,this coating achieves a combination of enhanced tissue integration,favorable hemocompatibility,and antioxidation functions,providing a solid reference for the surface functionalization of cardiovascular implant devices.关键词
微弧氧化/镁掺杂/抗菌性能/生物相容性/心血管植入器械Key words
micro-arc oxidation/Magnesium doping/antibacterial property/biocompatibility/cardiovascular implants分类
矿业与冶金引用本文复制引用
巨鹏亮,奚正星,赵金木,朱永都,马凤仓..镁掺杂微弧氧化TiO2多孔涂层的制备及其生物学性能研究[J].有色金属材料与工程,2026,47(3):39-48,10.基金项目
国家自然科学基金资助项目(51771119) （51771119）
上海市自然科学基金资助项目(17ZR1419600) （17ZR1419600）
