有色金属材料与工程2026，Vol.47Issue(3)：49-58,10.DOI:10.13258/j.cnki.nmme.20260228001
气管插管表面天然植酸复合抗菌抗痰栓涂层的制备与性能
Preparation and properties of natural phytic acid-based composite coating with antibacterial and anti-sputum properties on endotracheal tubes
徐勉 1何斌1
作者信息
- 1. 上海理工大学 健康科学与工程学院,上海 200093||上海交通大学医学院附属上海市胸科医院急重症医学科,上海 200030
- 折叠
摘要
Abstract
Prolonged endotracheal intubation can lead to complete occlusion of the tube lumen by sputum plugs and increases the risk of biofilm-associated infections,such as ventilator-associated pneumonia.To address these issues,this study constructed a PA-PHMB composite coating on the surface of endotracheal tubes using phytic acid(PA)and polyhexamethylene biguanide hydrochloride(PHMB),aiming to achieve both antibacterial and anti-sputum-plug effects.Compared with the unmodified catheter,the coating significantly improved the antibacterial properties and hydrophilicity of the endotracheal tube surface.The coating achieved bacterial eradication rates of 91.8%against Pseudomonas aeruginosa and 99.4%against Staphylococcus aureus,reduced protein adhesion by 61.4%,and decreased sputum plug formation by 59.5%,demonstrating excellent antibacterial and antifouling performance.The PA-PHMB composite coating developed in this study holds potential value for reducing endotracheal tube-associated infections and maintaining patient airway patency.关键词
气管插管/植酸/抗菌/抗痰栓Key words
endotracheal tube/phytic acid/antibacterial/anti-sputum plug分类
通用工业技术引用本文复制引用
徐勉,何斌..气管插管表面天然植酸复合抗菌抗痰栓涂层的制备与性能[J].有色金属材料与工程,2026,47(3):49-58,10.
