世界科学技术-中医药现代化2026，Vol.28Issue(8)：2493-2505,13.DOI:10.11842/wst.20250812002
犬尿氨酸途径代谢失衡:抑郁症发病机制及抗抑郁药物研发新思路
Metabolic Imbalance of the Kynurenine Pathway:The Pathogenesis of Depression and New Ideas for the Development of Antidepressant Drugs
摘要
Abstract
Depression is a highly heterogeneous mental disorder characterized primarily by persistent low mood and anhedonia,which significantly impair patients'social functioning and quality of life.In recent years,with the deepening of research into the neuroinflammatory mechanisms of depression,the kynurenine pathway,a key metabolic pathway of tryptophan has garnered significant attention.The metabolic products of this pathway primarily include quinolinic acid and kynurenic acid,and imbalances in their relative levels have been shown to be closely associated with the onset of depression.However,the mechanisms underlying this imbalance and its contribution to depressive symptoms remain unclear.This review examines the role of the kynurenine pathway in the pathophysiology of depression and the regulatory mechanisms of related drugs,aiming to further elucidate the pathogenesis of depression from a neuroinflammatory perspective and provide new insights for the development of antidepressant medications.关键词
抑郁症/发病机制/犬尿氨酸途径/犬尿酸/喹啉酸Key words
Depression/Pathogenesis/Kynurenine pathway/Kynurenic acid/Quinolinic acid分类
医药卫生引用本文复制引用
黄金清,祝有阳,赵连娜,牛志超,杨雪娇,雷娜,解宇环..犬尿氨酸途径代谢失衡:抑郁症发病机制及抗抑郁药物研发新思路[J].世界科学技术-中医药现代化,2026,28(8):2493-2505,13.基金项目
云南省科技人才和平台计划(202105AG070012):基于外侧缰核NMDAR/BDNF信号通路的丁香挥发油快速抗抑郁作用的机制研究,负责人:黄金清. （202105AG070012）
