针刺对青光眼眼压的调节:升高还是降低
Acupuncture regulation of intraocular pressure in glaucoma:Up or down
摘要
Abstract
Objective:The exact regulatory effect of acupuncture on intraocular pressure(IOP)in patients with glau-coma remains controversial.This review aimed to evaluate the current evidence regarding the effect of acupuncture on glaucomatous IOP and to identify the factors influencing therapeutic responses. Methods:A narrative review combined with exploratory stratified analysis was conducted.Relevant clini-cal studies were identified and evaluated to comprehensively analyze the clinical effects and mechanisms of acupuncture in the regulation of glaucomatous IOP.Furthermore,exploratory stratified analysis was applied to investigate key variables,including baseline IOP,glaucoma subtype,acupoint selection,and stimulation parameters. Results:Acupuncture induced three modulatory effects on IOP:reduction,biphasic changes(stress-induced elevation followed by reduction),and no significant effects,with IOP reduction being the pre-dominant pattern.The analysis revealed that this heterogeneity was primarily associated with the pa-tients' baseline IOP level and needle retention time;a higher baseline IOP correlated with a greater re-duction,whereas when the IOP was within the normal physiological range,acupuncture produced almost no further IOP-lowering effect.Acupuncture may indirectly improve the aqueous humor circulation by improving ocular blood circulation and modulating the autonomic nervous system.However,direct cellu-lar evidence of this is lacking. Conclusion:Current evidence suggests that acupuncture can effectively reduce pathologically elevated IOP in patients with glaucoma,particularly in those with a higher baseline IOP.However,its definitive long-term efficacy,ability to regulate 24 h IOP fluctuations,and whether it acts directly or indirectly on aqueous humor dynamics require further rigorous,large-scale clinical trials and in-depth molecular mechanistic studies.关键词
Acupuncture/Glaucoma/Intraocular pressure/Modulatory effectKey words
Acupuncture/Glaucoma/Intraocular pressure/Modulatory effect引用本文复制引用
雷一帆,薛世勇,樊晓鹏,王雪君,曹姚佳妮,孔谐和,郭浩东,马晓芃..针刺对青光眼眼压的调节:升高还是降低[J].世界针灸杂志（英文版）,2026,36(3):240-252,13.基金项目
This study was supported by Key Research Projects on the Modernization of Traditional Chinese Medicine,the National Key Research and Development Program of the Ministry of Science and Technology:2025YFC3508204,2025 National Major Difficult and Critical Diseases Integrated Traditional Chinese and West-ern Medicine Clinical Collaboration Project(13),High-level TCM Key Discipline of National Administration of Traditional Chinese Medicine:zyyzdxk-2023068,and Shanghai Clinical Medical Re-search on Acupuncture and Moxibustion:20MC1920500.The study sponsors had no role in the design and conduct of the study （13）
the collection,management,analysis,and interpretation of the data （）
the preparation,review,or approval of the manuscript （）
or the de-cision to submit the manuscript for publication. （）
