世界针灸杂志（英文版）2026，Vol.36Issue(3)：259-264,6.DOI:10.1016/j.wjam.2026.06.003
从单靶点到多维网络:针刺对偏头痛起效机制的研究进展
From single-target mechanisms to multi-target network regulation:Mechanisms of acupuncture in migraine
摘要
Abstract
Acupuncture has unique advantages in regulating neurotransmitters,improving vascular function,and in-hibiting inflammatory responses.However,most of these studies have been limited to the independent validation of a single target or pathway and have not yet clarified the synergistic relationships among various targets as a whole.Therefore,this study integrated existing research results to construct a multi-dimensional regulatory network for acupuncture in the treatment of migraine.Acupuncture intervention achieves analgesia through multiple targets,including the regulation of neurotransmitters,correction of vascular dilation and contraction functions,inhibition of neuroimmune inflammation,restoration of cen-tral pain regulation,and balance of endocrine levels.However,these targets are not independent of each other.Disruptions in the neurotransmitter balance can trigger abnormal vascular contraction and activate inflammatory responses,while the release of inflammatory factors can further sensitize pain transmis-sion and disrupt endocrine balance,forming a pathological vicious cycle.Acupuncture achieves synergis-tic analgesia through the coordinated intervention of multiple pathways,forming an interactive regula-tory network among the neural,vascular,immune,and endocrine systems,breaking the vicious cycle,and generating a synergistic analgesic effect.This multi-system,multi-targeted,coordinated regulation represents the core advantage of acupuncture's holistic therapeutic approach.关键词
Acupuncture/Migraine/Chinese traditional medicine/Nervous system diseasesKey words
Acupuncture/Migraine/Chinese traditional medicine/Nervous system diseases引用本文复制引用
向晗,朱才丰,杨高尚,周冰原,王雪伟,高大红,姜世豪..从单靶点到多维网络:针刺对偏头痛起效机制的研究进展[J].世界针灸杂志（英文版）,2026,36(3):259-264,6.基金项目
Supported by the Natural Science Foundation of An-hui Province:2208085MH273,the Anhui Province Tradi-tional Chinese Medicine Inheritance and Innovation Research Project:2024CCCX004,and the"Jiebang Guashuai"Program of the Major Science and Technology Special Project from Huatuo Insti-tute of Traditional Chinese Medicine,Anhui Province:BZKZ2402.The funder played no role in any aspect of the study,including the design,conduct,analysis,conception,planning,writing,and decision to publish the manuscript. （）
