世界中医药2026，Vol.21Issue(11)：1984-1990,7.DOI:10.3969/j.issn.1673-7202.2026.11.003
蒙药清热八味胶囊退热、抗炎药效学作用的初步评价
Preliminary Evaluation of the Antipyretic and Anti-inflammatory Pharmacodynamic Effects of Mongolian Medicine Qingre Bawei Capsules
摘要
Abstract
Objective:To preliminarily evaluate the antipyretic and anti-inflammatory effects of Mongolian medicine Qingre Bawei Capsules and explore their underlying mechanisms.Methods:A rat fever model was established by subcutaneous injection of dry yeast suspension.The effect of oral administration of Qingre Bawei Capsules on rat body temperature was evaluated.The levels of interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in rat serum,as well as prostaglandin E2(PGE2)and cyclic adenosine monophosphate(cAMP)levels in the hypothalamus,were determined using enzyme-linked immu-nosorbent assay(ELISA).A mouse acute ear edema inflammation model was established by topical application of xylene.The effect of oral administration of Qingre Bawei Capsules on mouse ear weight was evaluated,and the levels of inflammatory mediators,inclu-ding IL-1β,IL-6,and TNF-α,in mouse serum were measured using ELISA.Results:After subcutaneous injection of dry yeast sus-pension,the body temperature of rats increased significantly(≥0.8℃),indicating successful establishment of the fever model.Compared with the model group,oral administration of Qingre Bawei Capsules decreased the body temperature of febrile rats(P<0.001),significantly reduced the serum levels of inflammatory mediators IL-1β,IL-6,and TNF-α(P<0.05),and markedly de-creased the levels of PGE2 and cAMP in the hypothalamus(P<0.001).Mice exhibited obvious ear swelling after topical applica-tion of xylene,while the ear swelling degree was significantly reduced in the administration group(P<0.05),accompanied by a de-creased swelling rate and significantly reduced serum levels of inflammatory mediators IL-1β,IL-6,and TNF-α(P<0.01).Con-clusion:Qingre Bawei Capsules exert antipyretic and anti-inflammatory effects by reducing the expression levels of related inflam-matory mediators and alleviating inflammatory responses.Whether the antipyretic mechanisms are associated with inhibition of the PGE2 pathway requires further in-depth investigation.关键词
清热八味胶囊/退热/抗炎/白细胞介素-1β/白细胞介素-6/肿瘤坏死因子-α/前列腺素 E2/环磷酸腺苷Key words
Qingre Bawei Capsules/Antipyretic/Anti-inflammatory/Interleukin 1β/Interleukin 6/Tumor necrosis factor α/Prostaglandin E2/Cyclic adenosine monophosphate分类
医药卫生引用本文复制引用
史寒玲,曾鑫,杨建军,王长虹,尉小慧..蒙药清热八味胶囊退热、抗炎药效学作用的初步评价[J].世界中医药,2026,21(11):1984-1990,7.基金项目
国家科技部重点研发计划项目(2022YFC3501702). （2022YFC3501702）
