世界中医药2026，Vol.21Issue(11)：2013-2021,9.DOI:10.3969/j.issn.1673-7202.2026.11.007
基于数据挖掘的失眠动物模型应用分析
Application of Insomnia Animal Models Based on Data Mining
摘要
Abstract
Objective:To summarize and categorize existing animal models of insomnia and provide references for establishing in-somnia animal models that better reflect the characteristics of disease and syndromes in both traditional Chinese medicine(TCM)and Western medicine.Methods:Literature was retrieved from Chinese and English databases using"insomnia"and"animal mod-el"as subject terms.Data related to animal species,sex,body weight,modeling methods,criteria for determining successful model establishment,evaluation indicators,intervention methods,and positive control drugs were statistically analyzed.Results:A total of 143 articles were included.Insomnia models mainly used male Sprague Dawley(SD)rats and Wistar rats with body weights of 180 to 220 g.The primary modeling method was the induction of insomnia in rats using p-chlorophenylalanine,and model evaluation was mainly performed through observation of apparent changes.Frequently used evaluation indicators included the open field test,Morris water maze test,neurotransmitter detection,inflammatory mediator analysis,and brain tissue pathological examination.Inter-vention methods mainly involved Chinese herbal compound formulas,single Chinese herbs or extracts,and also included acupunc-ture and moxibustion,Western medicines,and Tuina.Diazepam was the most commonly used positive control drug in the experi-ments.Conclusion:Data mining analysis of insomnia animal models revealed limitations in current models,including weak correla-tions with TCM syndromes.In the future,insomnia models should be optimized using the concept of"disease-syndrome combina-tion"to provide a more precise experimental foundation for investigating the mechanisms of Chinese medicines and developing new drugs.关键词
失眠/数据挖掘/动物模型/病证结合/应用分析/造模方法/检测指标/中医证候Key words
Insomnia/Data mining/Animal model/Combination of disease and syndrome/Application analysis/Modeling meth-od/Detection indicators/Traditional Chinese medicine syndrome分类
医药卫生引用本文复制引用
张卓,李娅琪,季诗雨,黎柱江,吴艺璇,马作峰,黄攀攀..基于数据挖掘的失眠动物模型应用分析[J].世界中医药,2026,21(11):2013-2021,9.基金项目
国家自然科学基金项目(82374310 （）
82174247). （）
