世界中医药2026，Vol.21Issue(12)：2204-2210,7.DOI:10.3969/j.issn.1673-7202.2026.12.007
基于"痰浊"理论探讨氧化应激与慢性阻塞性肺疾病的关系
Relationship between Oxidative Stress and Chronic Obstructive Pulmonary Disease Based on the Phlegm Turbidity Theory
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a chronic airway disease closely associated with oxidative stress.In traditional Chinese medicine(TCM)theory,COPD is characterized by deficiency of the root and excess at the manifestation.Defi-ciency of the lung,spleen,and kidney leads to abnormal fluid metabolism and the formation of phlegm pathogens,with"phlegm tur-bidity"regarded as a core pathological factor that affects the progression and outcome of COPD.Studies have shown that the patho-logical mechanisms of"phlegm turbidity"are consistent with those of oxidative stress.Both are characterized by an imbalance in the internal environment of the body.Specifically,"phlegm"originates from an imbalance of yin and yang in the Zang-fu organs,re-sulting in abnormal fluid metabolism,whereas oxidative stress results from an imbalance between the oxidation and antioxidant sys-tems."Phlegm turbidity"has pathogenic characteristics of being ubiquitous and producing complex and variable symptoms,which are highly similar to the multisystem damage and pathological state driven by chronic inflammation induced by oxidative stress.Based on the theory of"phlegm turbidity",this article systematically elaborates on the key role of oxidative stress in COPD and proposes that treating"phlegm"through the lung,spleen,and kidney may regulate oxidative stress in a multitarget and systemic manner,thereby controlling the progression of COPD.This perspective aims to provide a new theoretical basis and therapeutic ap-proach for intervening in the oxidative stress state of COPD and delaying disease progression through the TCM treatment of"phlegm".关键词
慢性阻塞性肺疾病/痰浊/炎症反应/水液代谢/氧化应激/氧化-抗氧化/线粒体Key words
Chronic obstructive pulmonary disease/Phlegm turbidity/Inflammatory response/Fluid metabolism/Oxidative stress/Oxidation-antioxidation/Mitochondria分类
医药卫生引用本文复制引用
刘欣蕊,余阳,欧阳旭,刘潇潇,陈颖,赵凌..基于"痰浊"理论探讨氧化应激与慢性阻塞性肺疾病的关系[J].世界中医药,2026,21(12):2204-2210,7.基金项目
国家自然科学基金青年科学基金项目(82305008)——针刺通过肺部菌群/HIF-1α/PPAR-γ途径调控上皮-间质转化改善COPD气道重塑的机制研究 （82305008）
四川省自然科学基金项目(2025ZNSFSC1842)——针刺通过迷走神PVALB/肺NEB/Piezo2途径调控上皮-间质转化改善COPD气道重塑的机制研究. （2025ZNSFSC1842）
