生物加工过程2026，Vol.24Issue(4)：389-396,8.DOI:10.3969/j.issn.1672-3678.2026.04.005
不同类型的五环三萜类化合物的抑菌活性及构效关系
Antibacterial activity and structure-activity relationships of different types of pentacyclic triterpenoids
摘要
Abstract
This study investigates the antibacterial activities of 23 pentacyclic triterpenoids compounds with different structural types against five common pathogenic bacteria(Candida albicans,Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus and Streptococcus gordonii),and explores their antibacterial structure-activity relationships.The antibacterial activity of the compounds was preliminarily screened by the disc diffusion method,and the minimum inhibitory concentrations(MIC)were determined using the 2,3,5-triphenyltetrazolium chloride(TTC)staining method to evaluate antibacterial effects and analyze the correlation between structure and activity.The results demonstrated that pentacyclic triterpenoids with different structural types exhibited varying degrees of antibacterial effects against the five tested pathogenic strains.The lupane-type triterpenoids compounds,Danaxadiol and acantrifoside A,showed significant inhibitory effects against Staphylococcus aureus,with MIC values of 125.00 and 500.00 μg/mL,respectively.The ursane-type triterpenoid hydroxymadecassic acid showed inhibitory effects against Staphylococcus aureus,Escherichia coli,and Pseudomonas aeruginosa,with MIC values of 31.25,250.00,and 125.00 μg/mL,respectively.Further structure-activity analysis showed that the antibacterial activity of pentacyclic triterpenoids was significantly correlated with their core skeleton types and substituent groups,including carboxyl groups,hydroxyl groups,and glycosidic linkages.These results clarify the antibacterial characteristics and structure-activity relationships of pentacyclic triterpenoids,and provide a theoretical basis for the study of their antibacterial mechanisms and structural optimization.关键词
五环三萜类化合物/结构类型/抑菌活性/构效关系Key words
pentacyclic triterpenoids/structure type/antibacterial activity/structure-activity relationship分类
医药卫生引用本文复制引用
韦春玲,谭兴贵,陈杨,姜美泠,刘向前..不同类型的五环三萜类化合物的抑菌活性及构效关系[J].生物加工过程,2026,24(4):389-396,8.基金项目
湖南省自然科学基金(2024JJ7357) （2024JJ7357）
湖南中医药大学"十四五"重点学科——生物工程学科(校行发规字[2023]2号) （校行发规字[2023]2号）
