生物加工过程2026，Vol.24Issue(4)：397-405,425,10.DOI:10.3969/j.issn.1672-3678.2026.04.006
Cx43介导的阴茎海绵体纤维化在糖尿病性勃起功能障碍中的作用
The role of Cx43-mediated cavernous fibrosis in diabetes-induced erectile dysfunction
摘要
Abstract
Erectile dysfunction(ED)is a frequently observed complication for patients with type 2 diabetes(T2DM),with fibrosis of the corpus cavernosum as the primary pathological feature.Due to the close relationship of connexin 43(Cx43)with the fibrosis of endothelial cells,we investigated the potential involvement of Cx43 in the pathogenesis of diabetes-induced ED using a T2DM rat model induced by a high-fat diet/streptozotocin combination.As a result,chronic hyperglycemia significantly decreased erectile frequency and sexual behavior,lowered the intracavernous pressure/mean arterial pressure ratio,and increased fibrosis markers in the corpus cavernosum.Furthermore,the expression of Cx43 gene and protein significantly dropped in corpus cavernosum.Mechanistically,anomalous inactivation of the Wnt/β-catenin signaling pathway,marked by reduced Wnt-3a and β-catenin,was observed in the corpus cavernosum,which could partially block the transcription of Cx43.Moreover,hyperglycemia led to Src activation,as indicated by elevated levels of p-Src,which subsequently exacerbated the degradation of Cx43.Overall,our studies identified Cx43 hemichannels as conduits of diabetes-induced ED progression.Therapeutic strategies designed to increase or maintain Cx43 function may be beneficial to overcome fibrosis of the corpus cavernosum.关键词
勃起功能障碍/糖尿病/缝隙连接蛋白43/Wnt/β-catenin/海绵体纤维化Key words
erectile dysfunction/diabetes/Cx43/Wnt/β-catenin/cavernous fibrosis分类
医药卫生引用本文复制引用
孟琪,索嘉良,陈爽,李佳琪,马博,张琪..Cx43介导的阴茎海绵体纤维化在糖尿病性勃起功能障碍中的作用[J].生物加工过程,2026,24(4):397-405,425,10.基金项目
江苏省药品监督管理局药品监管科学科研计划(202406) （202406）
