生物加工过程2026，Vol.24Issue(4)：416-425,10.DOI:10.3969/j.issn.1672-3678.2026.04.008
基于UPLC-QTOF-MS/MS及网络药理学探讨茜草改善心肌损伤的物质基础及作用机制
Studies on cardioprotective mechanisms of Rubia cordifolia L.through UPLC-QTOF-MS/MS and network pharmacology
摘要
Abstract
Myocardial injury is a major factor in the progression of cardiovascular diseases.Through the combination of modern analytical techniques and systems biology approaches,we investigated thepharmacodynamic material basis and corresponding molecular mechanism with regards to the cardioprotective effects of Rubia cordifolia L.(RCL).Upon the chemical characterization of RCL extract by UPLC-QTOF-MS/MS,a herb-ingredient-target interaction network was constructed via network pharmacology to identify core therapeutic targets,which were further studied by molecular docking to evaluate the binding affinities with key active ingredients.As a result,18 chemical entities were identified,including mollugin and rubiatriol as potential bioactive components against myocardial injury,primarily through the interactions with BCL2,EGFR,ESR1 and MMP9.In conclusion,our study demonstrated that the amelioration of myocardial injury by RCL went through a multi-component,multi-target synergistic mechanism,providing a scientific basis for its quality control and rational clinical applications.关键词
茜草/网络药理学/UPLC-QTOF-MS/MS/分子对接Key words
Rubia cordifolia L./network pharmacology/UPLC-QTOF-MS/MS/molecular docking分类
医药卫生引用本文复制引用
王侃,王宇航,王安琪,孙雅晴,舒贝茜,高兰..基于UPLC-QTOF-MS/MS及网络药理学探讨茜草改善心肌损伤的物质基础及作用机制[J].生物加工过程,2026,24(4):416-425,10.基金项目
2024年江苏高校"青蓝工程"优秀青年骨干教师项目 （）
江苏省中药骨干人才高级研修项目(苏中医科教[2025]11号) （苏中医科教[2025]11号）
江苏省高等学校基础科学(自然科学)面上项目(21KJB360014) （自然科学）
