实用肝脏病杂志2026，Vol.29Issue(5)：669-672,4.DOI:10.3969/j.issn.1672-5069.2026.05.008
非酒精性脂肪性肝病患者肝脂肪变性严重程度对肠道菌群的影响
Intestinal flora changes in patients with non-alcoholic fatty liver disease
摘要
Abstract
Objective The aim of this study was to explore the correlation between intestinal flora changes and the severity of hepatic steatosis in patients with non-alcoholic fatty liver disease(NAFLD).Methods A cohort of 50 patients with NAFLD and 38 healthy individuals were recruited in our hospital between July 2024 and July 2025,and all patients with NAFLD underwent FibroScan for controlled attenuation parameter(CAP),by which hepatic steatosis was stratified as mild,moderate and severe degree.The composition of intestinal microbiota was analyzed by utilizing 16S rRNA gene high-throughput sequencing.Results Of the 50 patients with NAFLD,mild liver steatosis was found in 16 cases,moderate in 19 cases and severe in 15 cases;the abundances of Firmicutes,Faecalibacterium prausnitzii,Bifidobacterium,Anaerorhabdus and Blautia in patients with NAFLD were(5.1±1.2)％,(6.5±1.3)％,(7.1±1.9)％,(9.2±2.1)％and(11.8±2.9)％,all significantly lower than[(7.4±1.5)％,(10.4±2.1)％,(9.6±2.0)％,(12.3±2.6)％and(15.7±3.1)％,respectively,P＜0.05],while abundances of Bacteroidetes and Proteobacteria were(40.3±3.2)％and(7.4±1.5)％,both significantly higher than[(33.5±2.8)％and(4.6±1.1)％,respectively,P＜0.05]in healthy controls;the abundances of Firmicutes,Faecalibacterium prausnitzii,Bifidobacterium,Anaerorhabdus and Blautia in patients with severe NAFLD were(3.1±0.9)％,(5.1±1.0)％,(5.6±1.7)％,(7.4±1.5)％and(8.8±2.3)％,all significantly lower than[(5.3±1.3)％,(6.4±1.2)％,(7.1±1.9)％,(9.3±2.2)％and(12.1±3.1)％,respectively,P＜0.05]in those with moderate NAFLD or[(6.7±1.4)％,(7.9±1.7)％,(8.5±2.1)％,(10.8±2.5)％and(14.3±3.2)％,respectively,P＜0.05]in those with mild NAFLD,while abundances of Bacteroidetes and Proteobacteria were(44.4±3.2)％and(9.7±1.7)％,both significantly higher than[(41.2±3.3)％and(7.2±1.6)％,P＜0.05]in those with moderate NAFLD or[(35.4±3.1)％and(5.5±1.2)％,P＜0.05]in mild NAFLD.Conclusion There is a significant imbalance of intestinal flora in patients with NAFLD,which is manifested as decreased abundances of Firmicutes,Faecalibacterium prausnitzii,Bifidobacterium,Anaerorhabdus and Blautia,and increased abundances of Bacteroides and Proteobacteria,which needs further clarification.关键词
非酒精性脂肪性肝病/肠道菌群/肝脂肪变性/受控衰减参数Key words
Non-alcoholic fatty liver disease/Intestinal flora/Liver steatosis/Controlled attenuation parameter引用本文复制引用
李静,张文杰,杨晓娟,马蓉霞,陈芳芳..非酒精性脂肪性肝病患者肝脂肪变性严重程度对肠道菌群的影响[J].实用肝脏病杂志,2026,29(5):669-672,4.基金项目
甘肃省科技厅科研计划项目(编号:24JRRA706) （编号:24JRRA706）
