实用医学杂志2026，Vol.42Issue(16)：2937-2944,8.DOI:10.3969/j.issn.1006-5725.2026.16.009
外泌体在骨关节炎诊断和治疗中的现状、机遇与挑战
The current status,opportunities and challenges of exosomes in the diagnosis and treatment of osteoar-thritis
摘要
Abstract
Osteoarthritis(OA)is a highly prevalent degenerative joint disease that substantially impairs patients'quality of life.As key mediators of intercellular communication,exosomes have emerged as promising candidates for the diagnosis and therapeutic management of OA owing to their unique biological characteristics.This review summarizes the structural architecture and molecular composition of exosomes,appraises their poten-tial as diagnostic biomarkers for OA,and discusses their translational therapeutic value.We also delineate the cur-rent challenges encountered in clinical translation and outline future research directions,with the aim of providing a robust reference for advancing further investigation and clinical translation of exosome-based strategies in the OA research field.关键词
骨关节炎/外泌体/诊断/治疗Key words
osteoarthritis/exosomes/diagnosis/treatment分类
医药卫生引用本文复制引用
张晓非,徐康,孙逊..外泌体在骨关节炎诊断和治疗中的现状、机遇与挑战[J].实用医学杂志,2026,42(16):2937-2944,8.基金项目
天津市教委科研计划项目(编号:2025ZX012) （编号:2025ZX012）
京津冀基础研究合作专项(编号:23JCZXJC00050) （编号:23JCZXJC00050）
