天津中医药2026，Vol.43Issue(9)：1141-1150,10.DOI:10.11656/j.issn.1672-1519.2026.09.08
中医药治疗幽门螺杆菌感染随机对照试验用药方案及结局指标分析
Analysis of medication strategies and outcome indicators in randomized controlled trials of traditional Chinese medicine for treating Helicobacter pylori infection
摘要
Abstract
[Objective]To systematically retrieve and sort out the current status of randomized controlled trials(RCTs)on the treatment of Helicobacter pylori(Hp)infection with traditional Chinese medicine(TCM),present the results in the form of evidence mapping,and summarize the current evidence,progress,and existing issues in this field.[Methods]RCTs on the treatment of Hp infection with TCM published from January 2017 to June 2025 were retrieved from eight databases:CNKI,Wanfang Database,VIP,SinoMed,EMbase,Pubmed,Web of Science,and Cochrane Library.The quality of the literature was evaluated,and the medication strategies for both Western and Chinese medicines,as well as the setting of outcome measures,were analyzed.[Results]A total of 280 RCTs were included,with generally low quality of evidence,with issues such as non-standard antibiotic dosages and treatment durations,unclear primary and secondary outcome measures,confusion in the evaluation of composite outcome measures.[Conclusion]TCM has advantages in the treatment of Hp infection.Replacing one antibiotic with Chinese medicine and staged treatment expand the advantages of TCM,and provide a solution to the challenges in treating Hp infection.In the future,clinical design should be further standardized to enhance the quality of clinical research.Large-sample,multicenter RCTs should be conducted to provide high-quality evidence for the treatment of Hp infection with TCM.关键词
幽门螺杆菌/中医药/随机对照试验/质量评价/结局指标Key words
Helicobacter pylori/traditional Chinese medicine/randomized controlled trial/quality evaluation/outcome indicator分类
医药卫生引用本文复制引用
刘扬,江锋,庞晨旭,于艳卉,黄亚芳..中医药治疗幽门螺杆菌感染随机对照试验用药方案及结局指标分析[J].天津中医药,2026,43(9):1141-1150,10.基金项目
北京市东城区优秀人才培养项目(2019WJGW-10-04) （2019WJGW-10-04）
北京中医药大学东直门医院临床研究和成果转化能力提升试点项目(DZMG-ZJXY-23010). （DZMG-ZJXY-23010）
