畜牧与兽医2026，Vol.58Issue(10)：50-60,11.
单月桂酸甘油酯对雏鸡沙门菌感染的保护效应及肠道屏障调控
Protective effects of glycerol monolaurate against Salmonella infection and intestinal barrier modulation in chicks
摘要
Abstract
Glycerol monolaurate(GML)is a feed additive with multiple biological functions.This experiment aimed to study the effects of GML on chick health and its role in preventing and controlling Salmonella Enteritidis(SE)infection.Two-day-old SPF chicks were obtained and randomly divided into four groups:the controlgroup was fed with a basal diet,the GML group and the SE+GML group had 0.3%GML added to their diet,and the SE+GML group and the SE group were artificially infected with SE at 7 days of age.Then,growth performance,organ indices,blood biochemistry and immune indices,intestinal structure,and microbial flora of the chicks were measured.The results showed that the body weight of the chicks in the SE group was significantly lower than that in the other groups(P＜0.05),while the weight gain in the GML group and the SE+GML group was higher than that in the control group.The intestinal index of the chicks in the SE group was significantly reduced(P＜0.05),and GML addition increased the intestinal index of healthy and SE-infected chicks.Compared with the control group,the serum MDA,LDH,and AST contents in the GML group were significantly decreased(P＜0.05),the level of CATwas in-creased(P＜0.05);and the serum MDA,LDH,and AST levels in the SE+GML group were significantly lower than those in the SE group(P＜0.05).Compared with the control group,the IL-6 level in the GML group was significantly decreased(P＜0.05);the contents of MPO,TNF-α,and IFN-γ in the serum of chicks in the SE+GML group were lower than those in the SE group.Compared with the control group,the intestinal villus height of the chicks in the GML group was significantly increased(P＜0.01),and the villus height and villus-to-crypt ratio in the SE+GML group were significantly higher than those in the SE group(P＜0.05).SE infection led to a significant increase in the relative abundance of the[Ruminococcus]＿torques＿group in the chick intestine(P＜0.05),and 0.3%GML addition significantly in-creased the relative abundance of beneficial bacteria in the Lachnospiraceae＿NK4A136＿group and Shuttleworthia in the intestines of healthy and infected chicks(P＜0.05),and decreased the relative abundance of the[Ruminococcus]＿torques＿group(P＜0.05).In conclusion,adding 0.3%GML to the diet promoted the growth and antioxidant capacity of chicks,significantly alleviated the reduction in their body weight,stress injury,and inflammatory factor changes caused by SE infection,and improved the health of the body by regulating the intesti-nal structure and microbial flora of the chicks.关键词
单月桂酸甘油酯/肠炎沙门菌/生长性能/血液生化/肠道微生物/感染防控Key words
glycerol monolaurate/Salmonella Enteritidis/growth performance/blood biochemistry/intestinal microorganisms/infection prevention and control分类
农业科技引用本文复制引用
沈学怀,周学利,刘永杰,赵瑞宏,尹磊,侯宏艳,戴银,胡晓苗,殷冬冬,王洁茹,潘孝成..单月桂酸甘油酯对雏鸡沙门菌感染的保护效应及肠道屏障调控[J].畜牧与兽医,2026,58(10):50-60,11.基金项目
国家蛋鸡产业技术体系项目(CARS-39) （CARS-39）
安徽省农业科学院院立科研计划项目(2026YL037) （2026YL037）
农业农村部滁州野外综合科学观测站项目(MARA-ORS046-AH007,2026YL084) （MARA-ORS046-AH007,2026YL084）
安徽省家禽产业技术体系项目(AHCYJSTX-06) （AHCYJSTX-06）
