新医学2026，Vol.57Issue(9)：1012-1020,9.DOI:10.12464/j.issn.0253-9802.2025-0625
艾司氯胺酮在围手术期器官和系统保护的作用机制及临床研究进展
Mechanisms of action and advances in clinical research on esketamine in perioperative organ and system protection
摘要
Abstract
Esketamine is the S(+)-enantiomer of ketamine.As a novel anesthetic agent,it exerts its core pharmacological effects mainly through highly selective and potent antagonism of N-methyl-D-aspartate(NMDA)receptors.Compared with conventional ketamine,esketamine has advantages such as a faster onset of action,a shorter elimination half-life,rapid recovery,and a significantly lower incidence of neuropsychiatric adverse reactions.At the same time,it retains the characteristics of strong analgesic efficacy and mild inhibitory effects on respiratory and circulatory function.Therefore,it has attracted considerable attention in the fields of perioperative multimodal analgesia and organ function protection.Perioperative organ protection is a key focus in clinical practice and is of great significance for improving patient prognosis.This article systematically reviews the organ-protective mechanisms of esketamine in inhibiting inflammatory responses,alleviating oxidative stress,and suppressing apoptosis,and extends its protective effects from the traditionally emphasized heart,brain,and lungs to the digestive and immune systems.The article highlights the specific issues that need to be addressed in the translational process from laboratory mechanisms to clinical application,providing clear directions for future research.关键词
艾司氯胺酮/麻醉/围手术期器官/消化系统/免疫系统Key words
Esketamine/Anesthesia/Perioperative organs/Digestive system/Immune system分类
医药卫生引用本文复制引用
罗小丹,白福海..艾司氯胺酮在围手术期器官和系统保护的作用机制及临床研究进展[J].新医学,2026,57(9):1012-1020,9.基金项目
国家卫生健康委员会科学技术研究所科研项目(2024KYS01810-F.B) （2024KYS01810-F.B）
陆军军医大学第二附属医院青年博士人才培育计划(2023YQB007-F.B) （2023YQB007-F.B）
