新中医2026，Vol.58Issue(17)：1-6,6.DOI:10.13457/j.cnki.jncm.2026.17.001
加味真武汤联合盐酸伊伐布雷定片治疗慢性心力衰竭阳虚水泛证临床研究
Clinical Study of Modified Zhenwu Decoction Combined with Ivabradine Hydro-chloride Tablets in Treating Chronic Heart Failure with Yang Deficiency and Water Overflow Syndrome
摘要
Abstract
Objective:To observe the clinical efficacy of modified Zhenwu Decoction combined with Ivabradine Hydrochloride Tablets in treating chronic heart failure(CHF)with yang deficiency and water overflow syndrome.Methods:A total of 90 CHF patients with yang deficiency and water overflow syndrome admitted to Xuchang Hospital of Traditional Chinese Medicine from August 2023 to May 2025 were selected and randomly divided into a study group and a control group using the random number table method,with 45 cases in each group.All patients received conventional standard treatment.The control group received Ivabradine Hydrochloride Tablets,while the study group received modified Zhenwu Decoction in addition to the control group's regimen.Both groups were treated continuously for 12 weeks.Clinical efficacy was evaluated,and cardiac function,serological indicators,inflammatory factors,traditional Chinese medicine syndrome scores,and exercise tolerance were compared before and after treatment between the two groups.Results:The total effective rate was 95.56%(43/45)in the study group,significantly higher than that of 82.22%(37/45)in the control group(P＜0.05).After treatment,left ventricular end-diastolic dimension(LVEDD)decreased in both groups,while cardiac output(CO)and left ventricular ejection fraction(LVEF)increased(P＜0.05).The study group had lower LVEDD and higher CO and LVEF than the control group(P＜0.05).Soluble growth stimulation expressed gene 2 protein(sST2),growth differentiation factor-15(GDF-15),N-terminal pro-brain natriuretic peptide(NT-proBNP),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),and tumor necrosis factor-alpha(TNF-α)levels decreased in both groups(P＜0.05),with lower levels in the study group(P＜0.05).Traditional Chinese medicine syndrome scores decreased in both groups,while the 6-minute walking distance(6MWD)increased(P＜0.05).The study group had lower traditional Chinese medicine syndrome scores and a greater 6MWD than the control group(P＜0.05).No significant difference was observed in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Modified Zhenwu Decoction combined with Ivabradine Hydrochloride Tablets demonstrates good clinical efficacy in treating CHF with yang deficiency and water overflow syndrome.It alleviates heart failure symptoms,delays ventricular remodeling,reduces inflammatory factor levels,promotes exercise tolerance recovery,and exhibits favorable safety.关键词
慢性心力衰竭/阳虚水泛证/加味真武汤/盐酸伊伐布雷定片/中医证候/心功能/炎症因子Key words
Chronic heart failure/Yang deficiency and water overflow syndrome/Modified Zhenwu Decoction/Ivabradine Hydrochloride Tablets/Traditional Chinese medicine syndrome/Cardiac function/Inflammatory factors分类
医药卫生引用本文复制引用
李飞侠,马辉,刘振玉..加味真武汤联合盐酸伊伐布雷定片治疗慢性心力衰竭阳虚水泛证临床研究[J].新中医,2026,58(17):1-6,6.基金项目
河南省科技攻关项目(212102310132) （212102310132）
