Abstract
Objective To investigate correlation between body mass index(BMI)and abnormal fasting glucose and lipid metabolism in elderly population,and to evaluate the predictive value of BMI for these metabolic abnormalities.Methods A total of 1035 elderly individuals(aged 64-92 years)who underwent physical examination at Danfeng Community Health Service Center in Nanning from January 2020 to January 2022 were retrospectively enrolled.They were divided into four groups according to BMI:underweight group,normal weight group,overweight group,and obese group.Demographic data,physical indicators,and metabolic comorbidities were collected.Fasting plasma glucose(FPG),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were measured.In addition,intergroup comparison,Spearman correlation analysis,multivariate logistic regression analysis,and receiver operating characteristic(ROC)curve analysis were performed.Results There were statistically significant differ-ences in FPG,TG,LDL-C,and HDL-C levels,as well as in the prevalence of gender,waist circumference,hypertension,and fatty liver disease among different BMI groups(P＜0.05).Correlation analysis showed that BMI was positively correlated with FPG(r=0.123)and TG(r=0.080),and negatively correlated with HDL-C(r=-0.207)(allP＜0.01).Multivari-able logistic regression analysis showed that BMI was an independent factor associated with abnormal FPG(OR=1.540,95％CI:1.239-1.912),elevated TG(OR=1.201,95％CI:1.009-1.428),and reduced HDL-C(OR=1.633,95％CI:1.252-2.129)(all P＜0.05).ROC analysis showed that the area under the curve(AUC)of BMI for predicting abnormal FPG,elevated TG,and reduced HDL-C was 0.612(95％CI:0.569-0.655),0.536(95％CI:0.495-0.577),and 0.624(95％CI:0.573-0.676),respectively.The AUC of BMI combined with FPG and HDL-C for predic-ting elevated TG was 0.709(95％CI:0.670-0.748),which was numerically higher than that of BMI alone.Conclusion Elevated BMI is independently associated with abnormal FPG,elevated TG,and decreased HDL-C in the elderly popula-tion,but not significantly associated with TC or LDL-C.BMI has certain screening value for glucose and abnormal lipid me-tabolism,but its predictive efficacy alone is limited.In clinical practice,it should be combined with waist circumference,blood glucose,and blood lipid indicators for comprehensive assessment.关键词
老年人/体重指数/空腹血糖/血脂代谢异常/横断面研究/预测价值Key words
elderly population/body mass index(BMI)/fasting plasma glucose(FPG)/abnormal lipid metabolism/cross-sectional study/predictive value分类
医药卫生
