右江医学2026，Vol.54Issue(8)：783-790,8.DOI:10.3969/j.issn.1003-1383.2026.08.009
利用孟德尔随机化方法探索循环细胞因子与前列腺炎的关系
Causal relationship between circulating cytokines and the risk of prostatitis:a Mendelian randomization study
摘要
Abstract
Objective To explore causal relationship between circulating cytokines and prostatitis by Mendelian randomi-zation(MR).Methods Publicly available genome-wide association study(GWAS)summary statistics were utilized,and single nucleotide polymorphisms(SNPs)closely associated with circulating cytokines were selected as instrumental variables(IVs).The main method for MR analysis was inverse variance weighted(IVW).And then,the reliability of the results was examined by heterogeneity test,pleiotropy test and sensitivity analysis.Results IVW analysis showed that elevated levels of TRAIL(OR=1.17,95％CI=1.04-1.31)were associated with an increased risk of developing prostatitis,while de-creased levels of IL-18(OR=0.87,95％CI=0.77-0.98)and VEGF(OR=0.88,95％CI=0.79-0.99)were asso-ciated with an increased risk of developing prostatitis.Conclusion This study provides genetic evidence for the causal rela-tionship of IL-18,TRAIL,and VEGF in the pathogenesis of prostatitis,which suggests that they maybe served as potential therapeutic targets.关键词
前列腺炎/细胞因子/孟德尔随机化/炎症/因果关系Key words
prostatitis/cytokines/Mendelian randomization(MR)/inflammation/causal relationship分类
医药卫生引用本文复制引用
韦柳兴,李镇杰,卢保德,韦高猛..利用孟德尔随机化方法探索循环细胞因子与前列腺炎的关系[J].右江医学,2026,54(8):783-790,8.基金项目
广西卫生健康委员会自筹经费科研项目(Z20210912) （Z20210912）
