疑难病杂志2026，Vol.25Issue(9)：1043-1048,6.DOI:10.3969/j.issn.1671-6450.2026.09.004
血清ACSL4、sLOX-1、RETN在创伤合并脓毒症患者早期诊断和预后评估中的价值
Analysis of the value of serum ACSL4,sLOX-1,and RETN as potential biomarkers for early diagnosis and prognosis of trauma complicated with sepsis
摘要
Abstract
Objective To explore the value of serum long-chain acyl-CoA synthetase 4(ACSL4),soluble lectin-like oxidized low-density lipoprotein receptor 1(sLOX-1),and resistin(RETN)as potential biomarkers for the early diagnosis and prognosis of trauma complicated with sepsis(TS).Methods A total of 138 patients with TS treated in the Emergency De-partment of the First Affiliated Hospital of Xi'an Jiaotong University from February 2023 to February 2026 were selected as the TS group,and 120 patients with isolated trauma were selected as the control group.The TS group was further divided into a death subgroup(n=45)and a survival subgroup(n=93)based on 28-day follow-up outcomes.Serum levels of ACSL4,sLOX-1,and RETN were detected by ELISA.Factors influencing the prognosis of TS patients were analyzed.ROC curve analysis was used to evaluate the early diagnostic value of serum ACSL4,sLOX-1,and RETN for TS and their predictive effi-ciency for prognosis.In addition,the Bootstrap resampling method was employed to systematically validate the internal stabili-ty of the model.Results Compared with the control group,serum levels of ACSL4,sLOX-1,and RETN were significantly higher in the TS group(t=7.758,7.945,9.750;all P<0.001).Compared with the survival subgroup,the death subgroup had a significantly higher shock rate and significantly elevated serum levels of ACSL4,sLOX-1,and RETN(χ2/t=8.474,7.504,7.350,7.149;P=0.004,<0.001,<0.001,<0.001).Shock,high serum ACSL4,high sLOX-1,and high RETN were independent prognostic factors for TS patients[OR(95%CI)=3.286(1.426-7.573),3.575(1.891-6.760),2.983(1.647-5.402),6.883(3.052-15.525)].The AUCs of serum ACSL4,sLOX-1,RETN,and their combination for predicting poor prognosis in TS pa-tients were 0.801,0.763,0.869,and 0.935,respectively.The combined use of these three markers significantly outperformed individual predictions(Z=3.144,4.128,2.360;P=0.002,<0.001,0.018).Internal validation showed that the model's prediction curve was highly consistent with the actual observed data.Conclusion Serum levels of ACSL4,sLOX-1,and RETN are elevated in patients with TS.Combined detection of these three markers demonstrates superior diagnostic and prog-nostic efficiency for TS.关键词
创伤/脓毒症/长链酰基辅酶A合成酶4/可溶性凝集素样氧化低密度脂蛋白受体1/抵抗素/诊断/预后Key words
Trauma/Sepsis/Long-chain acyl-CoA synthetase 4/Soluble lectin-like oxidized low-density lipoprotein receptor 1/Resistin/Diagnosis/Prognosis分类
医药卫生引用本文复制引用
郝琳,李敏玲,周铜,孙阿巧..血清ACSL4、sLOX-1、RETN在创伤合并脓毒症患者早期诊断和预后评估中的价值[J].疑难病杂志,2026,25(9):1043-1048,6.基金项目
陕西省重点研发计划项目(2022ZDZM-SF-001) Key Research and Development Project of Shaanxi Province(2022ZDZM-SF-001) （2022ZDZM-SF-001）
