微创医学2026，Vol.21Issue(4)：403-412,10.DOI:10.11864/j.issn.1673.2026.04.01
现代创面修复技术系统评价与临床决策路径构建
Systematic review of modern wound repair technologies and construction of clinical decision-making pathways
摘要
Abstract
Wound repair represents a common challenge in clinical medicine.The concept of modern wound repair has undergone a paradigm shift from dry wound healing to moist wound healing.On this basis,a systematic diagnosis and treatment system centered on wound bed preparation(WBP)has been established.Among them,the internationally recognized TIME principle(Tissue debridement,Infection and inflammation control,Moisture balance,Edge of wound epithelialization)provides a standardized framework for assessment and intervention in clinical practice.This article aims to systematically elaborate four major clusters of modern clinical technologies based on the TIME principle:WBP technology,microenvironment regulation technology,active regeneration technology,and definitive closure and tissue substitution technology.By summarizing the mechanisms of action,clinical indications and evidence-based medical evidence of various technologies,a dynamic sequential clinical decision-making pathway for wounds is integrated.It is expected to provide theoretical reference and practical guidance for clinicians to formulate precise and individualized treatment regimens for complex refractory wounds.关键词
创面修复/湿性愈合/创面床准备/TIME原则/再生医学Key words
Wound repair/Moist wound healing/Wound bed preparation/TIME principle/Regenerative medicine引用本文复制引用
詹济滂,何仁亮..现代创面修复技术系统评价与临床决策路径构建[J].微创医学,2026,21(4):403-412,10.基金项目
广东省基础与应用基础研究基金自然科学基金面上项目(编号:2025A1515010822) （编号:2025A1515010822）
