医药导报2026，Vol.45Issue(9)：1477-1490,14.DOI:10.3870/j.issn.1004-0781.2026.09.001
雌二醇类药物用于辅助生殖超说明书用药专家共识
Expert Consensus on the Off-Label Use of Estradiol Drugs in Assisted Reproductive Technology
摘要
Abstract
With the rapid advancement of assisted reproductive technology(ART),an increasing number of infertile couples have achieved parenthood.Estradiol preparations play an irreplaceable role in key clinical procedures,including endometrial preparation for hormone replacement therapy-frozen-thawed embryo transfer(HRT-FET)and luteal phase support.However,the diversity of these agents and their routes of administration has led to prevalent off-label use and a lack of standardized guidance.To standardize the clinical use of estradiol in ART,the Consensus Development Group,following the World Health Organization(WHO)guideline development methodology,identified nine core clinical questions through a literature review and expert consultations.We systematically reviewed international and national databases to synthesize the best available evidence.Focusing on key aspects such as endometrial preparation protocols for HRT-FET,optimized management strategies for thin endometrium,indications and timing of estrogen administration in luteal phase support,and its application in GnRH antagonist protocols,the consensus ultimately formulated 15 recommendations.It clarified medication selection,routes of administration,dosage regimens,and treatment durations for various clinical scenarios.This consensus aimed to provide clinicians and pharmacists with practical,evidence-based references,facilitate the development of individualized treatment plans,optimize ART outcomes,ensure patient medication safety,and ultimately contribute to improving reproductive health services in China.关键词
雌二醇类药物/辅助生殖/超说明书用药/专家共识Key words
Estradiol preparations/Assisted reproductive technology/Off-label use/Expert consensus分类
医药卫生引用本文复制引用
吴越,何梦婕,吴雪花,熊婷婷,高羽,秦霞,秦博,何元媛,杨勇..雌二醇类药物用于辅助生殖超说明书用药专家共识[J].医药导报,2026,45(9):1477-1490,14.基金项目
国家自然科学基金面上项目(72574038) （72574038）
四川省自然科学基金面上项目(2026NSFSC0558) （2026NSFSC0558）
国家卫健委医院管理研究所医院药学高质量发展研究课题(智慧药学专项)(NIHAYSZX2520) （智慧药学专项）
四川省科教兴川医卫发展工作委员会横向项目(KJXC24-0201). （KJXC24-0201）
