养殖与饲料2026，Vol.25Issue(9)：23-28,6.DOI:10.13300/j.cnki.cn42-1648/s.2026.09.005
甘草酸对肉鸡生长性能、免疫功能和肠道形态的影响
Effects of glycyrrhizic acid on the growth performance,immune function,and intestinal morphology of broilers
摘要
Abstract
[Objectives]The effects of glycyrrhizic acid on the growth performance,immune function,and intestinal morphology of broilers were studied to provide a reference for its application in antibiotic-free farm-ing.[Methods]288 healthy yellow-feathered broilers aged 1 day(half male and half female,initial body weight of 36.8±1.2 g)were randomly and evenly divided into 4 treatment groups including the control group(CK),the low-dose group(GA50),the medium-dose group(GA100),and the high-dose group(GA150),with 6 repli-cates per group and 12 chickens per replicate.CK was fed with a basal diet.GA50,GA100,and GA150 added 50 mg/kg,100 mg/kg,and 150 mg/kg glycyrrhizic acid to the basal diet respectively.The experiment lasted 56 days.The indexes of growth performance,immune function,and intestinal morphology of broilers were mea-sured,and inter-group differences were statistically analyzed.[Results]Compared with the control group,the av-erage daily gain of broilers in GA100 and GA150 significantly increased from(33.15±1.78)to(35.17±1.67)and(34.92±1.56)g/d(P＜0.05),while the feed-to-gain ratio significantly decreased from 2.19±0.13 to 2.08±0.11 and 2.09±0.12(P＜0.05).The content of IgG and anti-inflammatory cytokine IL-10 in the serum of broilers in GA100 and GA150 was significantly increased from(6.42±0.45)to(7.15±0.57)and(7.18±0.54)mg/mL and from(26.43±1.04)to(38.36±1.08)and(39.73±1.06)pg/mL(P＜0.05),while the content of pro-inflammatory cytokines TNF-α and IL-6 was significantly decreased from(112.65±4.31)to(92.74±4.25)and(90.28±4.33)pg/mL and from(61.52±2.41)to(50.07±2.49)and(49.85±2.42)pg/mL(P＜0.05).The villus height in the duo-denum,jejunum,and ileum of broilers in GA100 and GA150 was significantly increased(P＜0.05).The crypt depth in the duodenum and jejunum was significantly shallower(P＜0.05),and the ratio of villus height to crypt depth(V/C)was consequently significantly improved(P＜0.05).[Conclusions]Diet supplemented with glycyrrhizic acid can improve the growth performance,immune function,and intestinal morphology of yellow-feathered broilers.100 mg/kg is the most suitable dose of supplementation based on analyzing compre-hensive indexes and taking cost into consideration.关键词
甘草酸/黄羽肉鸡/生长性能/免疫功能/肠道形态/抗生素替代Key words
glycyrrhizic acid/yellow-feathered broilers/growth performance/immune function/intestinal morphology/antibiotic alternatives引用本文复制引用
李燕舞,王强,张晓晶,张竹进,史学永,贾思锋..甘草酸对肉鸡生长性能、免疫功能和肠道形态的影响[J].养殖与饲料,2026,25(9):23-28,6.基金项目
潍坊市科技发展计划(2024ZJ1071) （2024ZJ1071）
