中草药2026，Vol.57Issue(18)：7086-7096,11.DOI:10.7501/j.issn.0253-2670.2026.18.002
中药抗肝纤维化研究进展
Research progress on traditional Chinese medicine against liver fibrosis
摘要
Abstract
Liver fibrosis is a chronic wound-healing response of the liver,essentially characterized by diffuse excessive deposition and abnormal distribution of the extracellular matrix(ECM).Although etiological therapy can slow fibrosis progression,drug development directly targeting the fibrotic process still faces substantial challenges,and clinical options remain extremely limited.Traditional Chinese medicine(TCM)has attracted extensive attention in the field of liver fibrosis research due to its multi-component,multi-target,and multi-pathway properties.However,current studies are still predominantly based on preclinical experiments,and systematic integration of mechanisms and sorting of clinical evidence are still inadequate.This review outlines the pathogenesis of liver fibrosis,with emphasis on the polarization of Kupffer cells,the capillarization of liver sinusoidal endothelial cells,the activation of hepatic stellate cells,and ECM metabolic imbalance.Antifibrotic effects of active components from herbs are summarized by chemical categories.Furthermore,the interactive network of signaling pathways is integrated from three hierarchical levels-the"inflammation initiation,metabolic regulation,and fibrotic progression"—to explore the systemic mechanisms underlying synergistic modulation by multiple components of TCM.Finally,the limitations of current research are identified,and future directions driven by cutting-edge technologies,including multi-omics integration,single-cell sequencing,artificial intelligence-based screening,and etiology-stratified precision therapy,are discussed.This review provides insights into mechanism interpretation and clinical translation of TCM against liver fibrosis.关键词
中药/肝纤维化/肝巨噬细胞/肝星状细胞/细胞外基质Key words
traditional Chinese medicine/liver fibrosis/Kupffer cells/hepatic stellate cells/extracellular matrix分类
医药卫生引用本文复制引用
周璇,赵文朵,王祖驰,齐双,李肖..中药抗肝纤维化研究进展[J].中草药,2026,57(18):7086-7096,11.基金项目
国家自然科学基金资助项目(82204656) （82204656）
博士后科学基金特别资助(2024T170534) （2024T170534）
山东省中医药科技项目(M20241725) （M20241725）
山东中医药大学中医药特色专项(KY2025T09) （KY2025T09）
山东省自然科学基金面上项目(ZR2026MS1262) （ZR2026MS1262）
