中草药2026，Vol.57Issue(18)：7097-7109,13.DOI:10.7501/j.issn.0253-2670.2026.18.003
中药通过抑制细胞衰老抗肺纤维化的研究进展
Research progress on traditional Chinese medicine on anti-pulmonary fibrosis by inhibiting cell senescence
摘要
Abstract
Pulmonary fibrosis(PF)is the terminal manifestation of various interstitial lung diseases.It is pathologically characterized by progressive destruction of alveolar structure and functional alveolar units,as well as persistent fibrosis of lung tissue.The prognosis is extremely poor,seriously affecting the quality of life of patients.In the pathological process of PF,there are typical"senescence-associated features"such as telomere shortening,resistance to apoptosis,and senescence-associated secretory phenotype.Cellular senescence,as one of the pathogenic mechanisms,plays an important role in the occurrence and development of PF.Studies have shown that the active ingredients of traditional Chinese medicine(TCM),single medicinal herbs and compound preparations of TCM can achieve the therapeutic effect of delaying the progression of PF by directly or indirectly inhibiting cellular senescence.Therefore,this article elaborates on the connection between cellular senescence and PF,summarizes the current research status of TCM in treating PF by inhibiting cellular senescence in recent years,and provides a reference for the clinical treatment of PF.关键词
肺纤维化/细胞衰老/衰老相关分泌表型/中药/间质性肺疾病Key words
pulmonary fibrosis/cellular senescence/senescence-associated secretory phenotype/traditional Chinese medicine/interstitial lung disease分类
医药卫生引用本文复制引用
宋子玉,刘勇明,李晓雯,卢雪茹,王佳然,王靖宇,张浩洋,臧凝子,庞立健,吕晓东..中药通过抑制细胞衰老抗肺纤维化的研究进展[J].中草药,2026,57(18):7097-7109,13.基金项目
国家自然科学基金区域联合基金项目(U24A20777) （U24A20777）
国家自然科学基金资助项目(82274440) （82274440）
国家自然科学基金资助项目(82204993) （82204993）
国家自然科学基金资助项目(82305157) （82305157）
国家自然科学基金资助项目(82505490) （82505490）
辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金资助项目(zyzx2503,zyzx2502) （zyzx2503,zyzx2502）
辽宁省科技厅博士启动项目(2025-BS-0721) （2025-BS-0721）
辽宁省教育厅高校基本科研项目(LJ222510162023) （LJ222510162023）
