中国病毒学2026，Vol.41Issue(4)：806-819,14.DOI:10.1016/j.virs.2026.07.008
Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication
Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication
摘要
关键词
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)/NSP8/PLpro/OTUB2/DeubiquitinationKey words
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)/NSP8/PLpro/OTUB2/Deubiquitination引用本文复制引用
Wenying Gao,Guangquan Li,Wenyan Zhang,Hongfei Wang,Jingguo Xin,Chenjia Gu,Lu Qiu,Xue Zhang,Chunlei Wang,Qingxiang Zhang,Shuai Li..Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication[J].中国病毒学,2026,41(4):806-819,14.基金项目
We thank C.Y.Dai for providing critical reagents and X.Liu for polishing the experimental methods.This work was supported in part by funding from the National Natural Science Foundation of China(82272304 to W.Y.Gao and 82272316 and 82341072 to W.Y.Zhang),Prevention and Control of Emerging and Major Infectious Diseases-Na-tional Science and Technology Major Project(2025ZD01904302 to W.Y.Zhang),the Science and Technology Department of Jilin Province(20240305089YY)and the Key Laboratory of Molecular Virology,Jilin Province(20102209),Bethune Medical Department Medicine+X Interdisciplinary Innovation Team Project(2024JBGS02). （82272304 to W.Y.Gao and 82272316 and 82341072 to W.Y.Zhang）
