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SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA

Liubing Du Zhenyu He Zhanjia Zhang Yu Yan Qitong Lin Yushan Xue Deyin Guo Ji-An Pan Yao-Qing Chen Xiaoxue Peng Xiaoyu Cai Ziliang Peng Mengxuan Wang Huijie Li Xue Liu Zhihui Zhang Manqi Cao Shuchun Zhang

中国病毒学2026，Vol.41Issue(4)：842-854,13.
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中国病毒学2026，Vol.41Issue(4)：842-854,13.DOI:10.1016/j.virs.2026.08.006

SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA

SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA

Liubing Du 1Zhenyu He 2Zhanjia Zhang 2Yu Yan 2Qitong Lin 2Yushan Xue 2Deyin Guo 3Ji-An Pan 4Yao-Qing Chen 5Xiaoxue Peng 6Xiaoyu Cai 5Ziliang Peng 2Mengxuan Wang 2Huijie Li 2Xue Liu 7Zhihui Zhang 2Manqi Cao 2Shuchun Zhang2

作者信息

  • 1. The Molecular Cancer Research Center,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China||The Division of Basic Research,Guangzhou National Laboratory,Bio-island,Guangzhou 510320,China
  • 2. The Molecular Cancer Research Center,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China
  • 3. The Division of Basic Research,Guangzhou National Laboratory,Bio-island,Guangzhou 510320,China
  • 4. The Molecular Cancer Research Center,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China||The Center for Infection and Immunity Study,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China
  • 5. School of Public Health(Shenzhen),Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China
  • 6. The Molecular Cancer Research Center,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China||The Center for Infection and Immunity Study,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China||Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases,Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China
  • 7. The Center for Infection and Immunity Study,Zhongshan School of Medicine,Sun Yat-sen University Shenzhen Campus,Shenzhen 518107,China
  • 折叠

摘要

关键词

SARS-CoV-2/Influenza virus/3C-like protease(3CLpro)/Nucleoprotein(NP)/Polymerase acidic protein(PA)

Key words

SARS-CoV-2/Influenza virus/3C-like protease(3CLpro)/Nucleoprotein(NP)/Polymerase acidic protein(PA)

引用本文复制引用

Liubing Du,Zhenyu He,Zhanjia Zhang,Yu Yan,Qitong Lin,Yushan Xue,Deyin Guo,Ji-An Pan,Yao-Qing Chen,Xiaoxue Peng,Xiaoyu Cai,Ziliang Peng,Mengxuan Wang,Huijie Li,Xue Liu,Zhihui Zhang,Manqi Cao,Shuchun Zhang..SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA[J].中国病毒学,2026,41(4):842-854,13.

基金项目

This work was supported by grants:National Key R&D Program of China(2025YFC2311600 for XP),China Postdoctoral Science Fund(2023M744081 for LD),Natural Science Foundation of China(#92569303 for YQC,#82150204 for XP,#32370159 and#82341057 for JAP and LD),Major Project of Guangzhou National Laboratory(GZNL2024A01008 for JAP),Regional Joint Key Project of Guangdong Province(2022B1515120038 for JAP),Shenzhen science and technol-ogy planning project(ZDSYS20220606100803007 for XP)and Shenz-hen Medical Research Fund(B2302044 for YQC,A2501026 for YY,and A2401035 for ZZ). （2025YFC2311600 for XP）

中国病毒学

1003-5125

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