中国当代儿科杂志2026，Vol.28Issue(9)：1086-1092,7.DOI:10.7499/j.issn.1008-8830.2605065
IgA血管炎肾炎伴新月体形成患儿的病理特征、治疗策略及预后评价
Pathological characteristics,therapeutic strategies,and prognostic assessment in children with crescentic IgA vasculitis with nephritis
摘要
Abstract
Objective To analyze the associations between crescent proportion and renal pathology,laboratory indicators,and prognosis in children with IgA vasculitis with nephritis(IgAVN),and to assess the impact of different treatment strategies on urinary protein and prognosis.Methods A total of 329 children with IgAVN and crescent formation were stratified by crescent proportion into a crescent<25%group and a crescent≥25%group.Relationships of crescent proportion and treatment strategies with pathological features,laboratory testing results and outcomes were evaluated.Results Compared with the crescent<25%group,the crescent≥25%group showed higher urine occult blood,urine protein,urinary N-acetyl-β-D-glucosaminidase,and serum urea levels,with decreased renal function and higher acute tubulointerstitial injury scores(P<0.05).Steroids combined with tripterygium glycosides,mycophenolate mofetil or Kunxian capsule all reduced the urine protein/creatinine ratio(P<0.001).The steroid plus Kunxian capsule regimen was associated with the best prognosis(P<0.05).Conclusions A higher crescent proportion is associated with more severe renal injury in pediatric IgAVN.Steroids combined with Kunxian capsule improves prognosis.关键词
IgA血管炎肾炎/新月体/治疗策略/预后/昆仙胶囊/儿童Key words
IgA vasculitis with nephritis/Crescent/Treatment strategy/Prognosis/Kunxian capsule/Child引用本文复制引用
张秋爽,杨晓青,梅晓峰,李金刚,白梦刻..IgA血管炎肾炎伴新月体形成患儿的病理特征、治疗策略及预后评价[J].中国当代儿科杂志,2026,28(9):1086-1092,7.基金项目
河南省科技研发计划联合基金(优势学科培育类)项目(232301420090) （优势学科培育类）
郑州市医疗卫生领域科技创新指导计划(2025YLZDJH316). （2025YLZDJH316）
