中国当代儿科杂志2026，Vol.28Issue(9)：1099-1105,7.DOI:10.7499/j.issn.1008-8830.2601123
伴TLS::ERG融合基因的儿童急性髓系白血病12例临床分析
Childhood acute myeloid leukemia with TLS::ERG fusion gene:a clinical analysis of 12 cases
摘要
Abstract
Objective To investigate the clinical characteristics and prognosis of pediatric acute myeloid leukemia(AML)with TLS::ERG fusion gene.Methods Clinical data from multiple pediatric hematology centers in South China were retrospectively reviewed for the period September 2015 to October 2025.Cases harboring the TLS::ERG fusion gene were identified and analyzed.Results Among 875 children with AML,12(1.4%)were TLS::ERG positive;there were 6 males and 6 females,with a median age of 88 months.The complete remission rate after 2 induction courses was 83%(10/12).Six patients relapsed,yielding a relapse rate of 50%(6/12).Four patients remained disease-free,six died after relapse,and two were lost to follow-up.The 5-year overall survival and event-free survival were 38.4%(95%CI:16.8%-87.8%)and 30.0%(95%CI:12.0%-74.7%),respectively.Conclusions Pediatric AML with TLS::ERG fusion is rare,shows a high early induction remission rate,but has a high relapse rate and poor prognosis.关键词
急性髓系白血病/TLS::ERG融合基因/C-HUANAN-AML-15方案/染色体易位/儿童Key words
Acute myeloid leukemia/TLS::ERG fusion gene/C-HUANAN-AML-15 protocol/Chromosomal translocation/Child引用本文复制引用
李湘,冯晓勤,贺湘玲,陈可可,田鑫,郑湧智,张本山,江华,杨丽华,麦惠容,徐宏贵..伴TLS::ERG融合基因的儿童急性髓系白血病12例临床分析[J].中国当代儿科杂志,2026,28(9):1099-1105,7.基金项目
湖南省科技创新计划项目(2024JJ9153). （2024JJ9153）
