中国康复理论与实践2026，Vol.32Issue(9)：1016-1024,9.DOI:10.3969/j.issn.1006-9771.2026.09.003
中枢听觉测验联合脑电特征在阿尔茨海默病源性轻度认知障碍早期筛查中的应用
Application of central auditory testing combined with electroencephalogram characteristics in the early screening of mild cognitive impairment due to Alzheimer's disease
摘要
Abstract
Objective To investigate the application of central auditory testing combined with electroencephalographic features in the early screening of mild cognitive impairment due to Alzheimer's disease. Methods A convenience sampling method was used to conduct a field survey in the Qixia District of Nanjing City,Jiang-su Province,from July to September,2025.A total of 40 older adults diagnosed as mild cognitive impairment due to Alzheimer's disease and 23 cognitively normal older adults were recruited.Auditory N-back and dichotic lis-tening paradigms were employed for assessment,while the scores of Montreal Cognitive Assessment Beijing Ver-sion(MoCA-BJ)and 32-channel electroencephalogram(EEG)data were simultaneously collected.Binary logis-tic regression analysis was applied to identify predictive indicators,receiver operating characteristic(ROC)curves were plotted,and the area under the curve(AUC)was calculated. Results The total score of dichotic listening was positively correlated with overall cognitive function(r=0.475,P<0.01),while right-ear advantage showed negative correlations with overall cognition,visuospatial ability,abstract reasoning,and delayed recall(r<-0.276,P<0.05).Task performance across all conditions of the N-back task was positively correlated with overall cognitive function(r>0.249,P<0.05).Regarding EEG features,δ and θ band power and power peaks were positively correlated with delayed recall(r>0.258,P<0.05),whereas(α+θ)/(α+β)and θ/(α+β)were positively correlated with naming ability and visuospatial executive function,respective-ly(r>0.261,P<0.05).The results of the binary logistic regression analysis showed that the total score of binau-ral dichotic listening,the accuracy of 1-back task,the average power of δ waves,and the ratio of θ/(α+β)were in-dependent influencing factors for mild cognitive impairment due to Alzheimer's disease(P<0.05).The ROC analysis indicated that the AUC for auditory task performance and EEG features were 0.845 and 0.735 respective-ly,and when combined,the AUC increased to 0.862. Conclusion The screening model based on the integration of auditory task performance and EEG features can be used in the early identification of mild cognitive impairment due to Alzheimer's disease.关键词
阿尔茨海默病源性轻度认知障碍/中枢听觉测验/脑电/老年人/早期筛查Key words
mild cognitive impairment due to Alzheimer's disease/central auditory test/electroencephalogram/older adults/early screening分类
医药卫生引用本文复制引用
孙凤仪,殷海燕,尹婷婷,杨冰清,顾剑鹏,汪妍,柏亚妹,徐桂华,宋玉磊..中枢听觉测验联合脑电特征在阿尔茨海默病源性轻度认知障碍早期筛查中的应用[J].中国康复理论与实践,2026,32(9):1016-1024,9.基金项目
1.国家重点研发计划项目(No.2023YFC3603600) （No.2023YFC3603600）
2.江苏高校优势学科四期项目南京中医药大学护理学科开放课题(No.YSHL202503) （No.YSHL202503）
3.江苏省研究生实践创新计划课题(No.SJCX25_0908) Supported by National Key Research and Development Program of China(No.2023YFC3603600),the Open Projects of the Discipline of Nursing of Nanjing University of Chinese Medicine Supported by Superior Discipline Phase IV Project of Jiangsu Higher Education Institutions(No.YSHL202503),and Postgraduate Practice Innovation Program of Jiangsu Province(No.SJCX25_0908) （No.SJCX25_0908）
