中国临床药理学与治疗学2026，Vol.31Issue(8)：1085-1090,6.DOI:10.12092/j.issn.1009-2501.2026.08.009
双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估
Effect of bicyclol in abnormal liver function induced by chemothera-py in gynecologic tumors
摘要
Abstract
AIM:To explore the effect of bicyclol in preventing and treating abnormal liver function indexs,which induced by chemotherapy in gyneco-logic tumors.METHODS:A total of 40 patients with abnormal liver function indices induced by chemotherapy for gynecologic tumors were select-ed from 2020 to 2022.They were divided into the bicyclol treatment group and the glycyrrhizin treat-ment(oral diammonium glycyrrhizinate enteric-coated capsules or compound glycyrrhizin tablets).Compared the changes in liver function indexs to evaluate the effect and adverse reaction between the two groups.RESULTS:After chemotherapy,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl trans-ferase(GGT),alkaline phosphatase(ALP),total bilirubin(TBIL),and direct bilirubin(DBIL)elevated.Following hepatoprotective treatment,these in-dexs decreased in both groups.Bicyclol tables re-duced ALT more significantly than glycyrrhizin group(P<0.05).There was not adverse reactions in either group.CONCLUSION:Oral glycyrrhizin and bicyclol tablets are both effective in alleviating abnormal liv-er function indices caused by chemotherapy in gy-necologic tumors.Compared to oral glycyrrhizin,bi-cyclol tablets demonstrate a superior effect in re-ducing liver enzyme levels.Patients with significant-ly elevated liver enzyme levels should consider bicy-clol tablets as the preferred treatment option.关键词
双环醇片/甘草酸口服制剂/妇科肿瘤化疗/肝功能指标异常Key words
bicyclol tablet/oral glycyrrhizin/gyne-cologic tumor chemotherapy/abnormal liver func-tion index分类
医药卫生引用本文复制引用
刘婷婷,胡梦雪,刘亚如,叶翀,夏泉..双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估[J].中国临床药理学与治疗学,2026,31(8):1085-1090,6.基金项目
国家自然科学基金青年科学基金资助项目(81903622) （81903622）
安徽省高等学校省级质量工程项目(2023jyxm0981) （2023jyxm0981）
安徽省教育厅高校优秀拔尖人才培育项目(gxgwfx2021016) （gxgwfx2021016）
新安医学教育部重点实验室开放课题(2024xayx06) （2024xayx06）
安徽省高校自然科学研究项目(2023AH053290) （2023AH053290）
安徽省转化医学研究院科研基金项目(2022zhyx-C30) （2022zhyx-C30）
