中国临床药理学与治疗学2026，Vol.31Issue(8)：1091-1100,10.DOI:10.12092/j.issn.1009-2501.2026.08.010
miRNA调控原发性干燥综合征的作用机制研究进展
Research progress on the mechanism of miRNA in regulating primary Sjögren's syndrome
摘要
Abstract
Primary Sjögren's syndrome(pSS)is a chronic systemic autoimmune disorder whose pathogenesis remains incompletely understood.The current treatment options are limited and there is no curative therapy.microRNA(miRNA),as im-portant post-transcriptional regulatory factors,can widely participate in the pathological processes such as immune dysregulation and tissue damage in pSS,providing new research directions for its diag-nosis and treatment.When pSS occurs,the expres-sion of miRNAs in the body will be abnormal.By regulating the expression of miRNAs,it can affect the prognosis and outcome of pSS.Therefore,miR-NAs are considered as an important target for anti-pSS treatment.Studies have found that miR-216a-3p,miR-31-5p,etc.,can regulate the polarization of macrophages,cell apoptosis,Th17/Treg balance,T/B lymphocytes,glandular function,and type Ⅰ IFN response through regulating the NF-κB,JAK/STAT,and PI3K/AKT signaling pathways,thereby regulat-ing the occurrence and development of pSS.This ar-ticle reviews the regulatory mechanisms of miRNAs on pSS,with the aim of providing ideas and basis for the prevention and treatment of pSS.关键词
miRNA/原发性干燥综合征/作用机制/研究进展Key words
miRNA/primary Sjögren's syndrome/mechanism of action/research progress分类
医药卫生引用本文复制引用
王成志,李松伟,刘一帆,杜萌萌,朱柯颖,李桓..miRNA调控原发性干燥综合征的作用机制研究进展[J].中国临床药理学与治疗学,2026,31(8):1091-1100,10.基金项目
国家自然科学基金面上项目(81874465) （81874465）
国家青年科学基金项目(82405297) （82405297）
中国博士后科学基金第71批面上项目(2022M711083) （2022M711083）
中国博士后科学基金第76批面上项目(2024M763850) （2024M763850）
国家中医药管理局科技专项课题(GZY-KJS-2025-080) （GZY-KJS-2025-080）
河南中医药大学研究生科研创新能力提升专项课题(2025KYCX005) （2025KYCX005）
河南中医药大学第一附属医院博士科研启动金(CZ0377-14) （CZ0377-14）
河南省卫生健康委国家中医药传承创新中心联合共建科研专项课题(2024ZXZX1091) （2024ZXZX1091）
