中国临床医学影像杂志2026，Vol.37Issue(9)：629-634,6.DOI:10.12117/jccmi.2026.09.005
增强CT、PET/CT及放射组学特征在非鳞非小细胞肺癌中的应用
Application of enhanced CT,PET/CT,and radiomic features in non-squamous non-small cell lung cancer
摘要
Abstract
Objective:To evaluate the predictive value of contrast-enhanced CT,PET/CT metabolic parameters,and radiomics features for treatment response and survival in patients with non-squamous non-small cell lung cancer(NSCLC)receiving tislelizumab plus bevacizumab.Methods:A total of 120 patients with non squamous NSCLC were retrospectively included.Baseline and on-treatment contrast-enhanced chest CT and PET/CT were performed.CT volumetric indicators,PET metabolic parameters,and radiomics features were extracted.Survival analyses,multivariable Cox regression,and radiomics-based machine learning models were used to assess predictive performance.Results:Objective response rate(ORR)was 43.3％and disease control rate(DCR)was 81.7％;median PFS and OS were 13.54 and 19.36 months,respectively.Base-line CT_vol,MTV,and TLG were significantly associated with treatment outcomes,and≥30％decline in PET metabolic parameters at 6～9 weeks predicted prolonged PFS.A radiomics-clinical nomogram achieved an AUC of 0.784 and outper-formed conventional imaging metrics.Treatment-related adverse events were manageable.Conclusion:PET metabolic parameters,CT volumetrics,and radiomics features provide significant predictive value for treatment response and survival in non-squamous NSCLC,supporting individualized treatment decision-making for tislelizumab plus bevacizumab therapy.关键词
肺肿瘤/癌,非小细胞肺/体层摄影术,X线计算机/正电子发射断层显像计算机体层摄影术Key words
Lung Neoplasms/Carcinoma,Non-Small-Cell Lung/Tomography,X-Ray Computed/Positron Emission Tomography Computed Tomography分类
医药卫生引用本文复制引用
成炜,葛珊珊,黄敏,王祎,曹雨凤,邓广均..增强CT、PET/CT及放射组学特征在非鳞非小细胞肺癌中的应用[J].中国临床医学影像杂志,2026,37(9):629-634,6.基金项目
南通市卫生健康委员会科研项目(MS2023128) （MS2023128）
江苏省卫生健康委科研项目(M2021085). （M2021085）
