中国脑血管病杂志2026，Vol.23Issue(8)：549-559,11.DOI:10.3969/j.issn.1672-5921.2026.08.006
动脉瘤性蛛网膜下腔出血早期脑损伤相关分子标志物及可干预通路研究进展
Advances in molecular biomarkers and targetable pathways in early brain injury after aneurysmal subarachnoid hemorrhage
唐杰 1孙军 1徐佳明 1魏衍鹏 1易守明 1张宾锐1
作者信息
- 1. 325000 温州医科大学附属温州市中心医院神经外科
- 折叠
摘要
Abstract
Aneurysmal subarachnoid hemorrhage(aSAH)is an acute and severe neurosurgical emergency with high mortality and disability.Early brain injury(EBI)is an important factor affecting acute disease progression and long-term outcome after aSAH and its mechanisms involves blood-brain barrier disruption,microcirculatory dysfunction,brain edema,neuroinflammation,toxicity of hemoglobin degradation products,iron homeostasis disorder and regulated cell death.This review summarized the detectable molecular biomarkers and potentially targetable pathways in the key pathological processes of EBI after aSAH,aiming to provide a reference for the early identification of high-risk patients and the selection of therapeutic targets.关键词
动脉瘤性蛛网膜下腔出血/早期脑损伤/分子标志物/靶向治疗/综述Key words
Aneurysmal subarachnoid hemorrhage/Early brain injury/Molecular biomarkers/Targeted therapy/Review引用本文复制引用
唐杰,孙军,徐佳明,魏衍鹏,易守明,张宾锐..动脉瘤性蛛网膜下腔出血早期脑损伤相关分子标志物及可干预通路研究进展[J].中国脑血管病杂志,2026,23(8):549-559,11.
