中国普通外科杂志2026，Vol.35Issue(7)：1299-1311,13.DOI:10.7659/j.issn.1005-6947.260211
肝胆胰外科器官功能保留的范式转变:从解剖导向到功能导向的理论与实践
Paradigm shift in organ function preservation in hepatopancreatobiliary surgery:from anatomy-oriented to function-oriented strategies
摘要
Abstract
With the advancement of hepatopancreatobiliary surgery,the traditional treatment paradigm centered on anatomical resection and structural reconstruction is gradually evolving toward function-oriented decision-making.Increasing evidence indicates that achieving R0 resection and anatomical patency alone is insufficient to optimize long-term outcomes,whereas postoperative loss of organ function,accompanied by metabolic disturbances,nutritional impairment,and reduced quality of life,has become a major determinant of long-term prognosis.Nevertheless,functional preservation poses distinct challenges across different organs.In liver surgery,discrepancies between residual liver volume and actual functional reserve limit the accuracy of current assessment systems.In pancreatic surgery,preservation of pancreatic function is intrinsically constrained by the increased risk of postoperative pancreatic fistula,creating a dilemma between short-term safety and long-term metabolic benefits.In biliary surgery,anatomical reconstruction does not necessarily ensure functional recovery,and increasing attention has been directed toward abnormalities in bile flow dynamics and biliary microbiota homeostasis.This review systematically summarizes the theoretical basis and clinical advances of organ function preservation in the liver,pancreas,and biliary system from the perspectives of functional assessment,surgical decision-making,and underlying biological mechanisms.It further proposes several function-oriented concepts,including the"territory-function balance"in liver surgery,the"function-risk trade-off"in pancreatic surgery,and the"functional safety window"in biliary surgery.Future progress in hepatopancreatobiliary surgery is expected to shift from the pursuit of anatomical success alone toward the establishment of function-oriented decision-making systems,aiming to achieve optimal organ function,metabolic homeostasis,and quality of life while maintaining oncological safety.关键词
消化系统外科手术/器官功能保留/精准外科/功能评估/肝再生/胰腺功能/胆道重建Key words
Digestive System Surgical Procedures/Organ Function Preservation/Precision Surgery/Functional Assessment/Liver Regeneration/Pancreatic Function/Biliary Reconstruction分类
医药卫生引用本文复制引用
吴涛,本田五郎,黄洁..肝胆胰外科器官功能保留的范式转变:从解剖导向到功能导向的理论与实践[J].中国普通外科杂志,2026,35(7):1299-1311,13.基金项目
国家自然科学基金资助项目(82460518) （82460518）
云南省医学学科带头人培养计划基金资助项目(D-2024030) （D-2024030）
云南省外国专家基金资助项目(202605AP120001). （202605AP120001）
