中国实验动物学报2026，Vol.34Issue(8)：1189-1195,7.DOI:10.3969/j.issn.1005-4847.2026.08.009
心肌缺血再灌注损伤动物模型构建的回顾与评价
Systematic evaluation of animal model construction for myocardial ischemia-reperfusion injury
摘要
Abstract
Acute myocardial infarction exhibits a high global occurrence rate and mortality.The primary therapeutic objective for this condition is to rapidly restore coronary artery blood flow,thereby mitigating the progression of myocardial ischemia and infarction.However,during the restoration of blood perfusion to ischemic tissues,a series of significant pathophysiological alterations frequently occur in cardiac cells and the local microvascular network within the reperfused area.These changes collectively contribute to further damage of the myocardial tissue,a phenomenon referred to as myocardial ischemia-reperfusion injury(MIRI).Currently,the precise pathological mechanisms underlying MIRI have not been systematically elucidated.The lack of animal models that can ideally simulate this pathological process represents one of the critical factors limiting the development of effective prevention and treatment strategies.This article aims to systematically review the method ologies for establishing animal models of myocardial ischemia-reperfusion injury,with the goal of providing a theoretical foundation for related basic research and clinical therapeutic practices.关键词
心肌梗死/心肌缺血再灌注损伤/基础实验/动物模型Key words
myocardial infarction/myocardial ischemia-reperfusion injury/basic experiments/animal model分类
生物科学引用本文复制引用
杨文娜,郑景辉,熊小奇,朱仕现,范晓茜..心肌缺血再灌注损伤动物模型构建的回顾与评价[J].中国实验动物学报,2026,34(8):1189-1195,7.基金项目
国家自然科学基金(82160875),广西中医药大学联合基金(2023LZ016).Funded by National Natural Science Foundation of China(82160875),Guangxi University of Traditional Chinese Medicine Joint Fund(2023LZ016). （82160875）
