子宫内膜异位症病证结合动物模型的建立及评价方法研究
Establishment and evaluation methods of animal models of endometriosis
摘要
Abstract
Endometriosis(EMS)represents a prevalent gynecological disorder capable of inducing pelvic pain and infertility.There has been an upward trend in the incidence of endometriosis in recent years.Traditional Chinese medicine(TCM)has demonstrated extensive clinical experience in treating endometriosis,with advantages such as minimal side effects and a reduced recurrence rate.It is important to establish an animal model of endometriosis with the dual characteristics of disease and TCM syndromes to support its further study.This review presents the preparation method and evaluation indexes of animal models of the common syndromes of endometriosis,such as qi stagnation and blood stasis type,cold coagulation and blood stasis type,kidney deficiency and blood stasis type,qi deficiency and blood stasis type,and heat burning and blood stasis type.The aim is to provide a theoretical foundation for subsequent syndrome-differentiation and treatment in TCM clinical practice.关键词
子宫内膜异位症/病证结合/动物模型/中医证候/模型评价Key words
endometriosis/combination of disease and syndrome/animal model/Chinese medicine syndromes/model evaluation分类
生物科学引用本文复制引用
施恭宁,徐陈琳,付欣慧,冯晓雨,焦坤,童黄锦..子宫内膜异位症病证结合动物模型的建立及评价方法研究[J].中国实验动物学报,2026,34(8):1196-1210,15.基金项目
国家自然科学基金项目(82305010),江苏省中药骨干人才高级研修项目(苏中医科教(2022)17号),中药制药过程控制与智能制造技术重点实验室开放基金课题(SKL2024Z0109),江苏省高层次人才培养计划("333工程")培养对象(苏人才(2024)2号,(2024)3-2260号),2025年阜阳市重点研究与开发计划项目(FK20253301).Funded by the National Natural Science Foundation of China(82305010),Jiangsu Province Chinese Medicine Backbone Talent Advanced Training Project(Jiangsu Traditional Chinese Medicine Science and Education(2022)No.17),Open Fund Project of Key Laboratory of Pharmaceutical Process Control and Intelligent Manufacturing Technology of Traditional Chinese Medicine(SKL2024Z0109),the Training Object of Jiangsu Provincial High-Level Talents Training Plan("333 Project")(Su Talents(2024)No.2,(2024)No.3-2260),Fuyang Key Research and Development Plan Project in 2025(FK20253301). （82305010）
