中国实验方剂学杂志2026，Vol.32Issue(17)：70-76,7.DOI:10.13422/j.cnki.syfjx.20260606
基于"重阳"理论探讨老年失眠线粒体功能障碍的机制及治疗思路
Exploring Mechanism and Treatment of Senile Insomnia Based on Theory of Extreme Yang
摘要
Abstract
Senile insomnia is a common clinical disorder.Traditional Chinese medicine(TCM)primarily attributes the pathogenesis of insomnia to Yang failing to enter Yin aspect and disharmony between Yin and Yang.However,the discussion on insomnia caused by Yang Qi deficiency in elderly patients remains insufficient.According to the theory of extreme Yang in the Huang Di Nei Jing,this paper systematically elucidates the central role of Yang Qi in maintaining mental tranquility and regulating the sleep-wake cycle.It posits that the natural decline of Yang Qi with aging leads to Yang failing to enter Yin aspect or deficient Yang floating upward,which constitutes a key pathogenesis of senile insomnia.From a modern medical perspective,mitochondrial energy metabolism dysfunction is identified as a crucial biological basis.Mitochondrial functional declines result in insufficient adenosine triphosphate(ATP)production and reactive oxygen species(ROS)accumulation,which disrupts the synthesis of sleep-related neurotransmitters and the expression of circadian clock genes,ultimately leading to sleep disturbances.Furthermore,this sutdy explores the intrinsic connection between Yang Qi deficiency and mitochondrial dysfunction,arguing for a high degree of correspondence in their functional and pathological manifestations.Accordingly,the therapeutic principle of warming and tonifying Yang Qi,nourishing the heart and tranquilizing the mild is proposed.This approach employs Yang-warming formulas and acupuncture to regulate the mitochondrial function through multiple targets.Specific mechanisms include enhancing the activity of respiratory chain complexes,activating the mitochondrial autophagy,and mitigating oxidative stress,thereby restoring energy metabolic homeostasis and improving sleep in the elderly.This study provides a new theoretical foundation and a therapeutic strategy for integrating TCM and Western medicine in preventing and treating senile insomnia.关键词
《黄帝内经》/重阳/线粒体功能障碍/老年失眠Key words
Huang Di Nei Jing/extreme Yang/mitochondrial dysfunction/senile insomnia分类
医药卫生引用本文复制引用
马金旭,夏婧,徐波,谢光璟..基于"重阳"理论探讨老年失眠线粒体功能障碍的机制及治疗思路[J].中国实验方剂学杂志,2026,32(17):70-76,7.基金项目
国家自然科学基金项目(82305354) （82305354）
