中国实用外科杂志2026，Vol.46Issue(8)：1042-1045,1049,5.DOI:10.19538/j.cjps.issn1005-2208.2026.08.06
系统治疗背景下对胰腺癌手术指征再认识
Rethinking the indications for pancreatic cancer surgery in the context of systemic therapy
摘要
Abstract
Locally advanced pancreatic cancer(LAPC)has long been classified as unresectable pancreatic cancer owing to invasion of adjacent vital blood vessels.In recent years,with advances in surgical techniques and the widespread adoption of updated systemic treatment,a subset of patients with LAPC can achieve access to radical surgery after conversion therapy.Accordingly,the evaluation of surgical indications is transitioning from the traditional imaging-based anatomical assessment to a comprehensive evaluation integrating biological behavior and anatomical alterations.Assessment of tumor-vessel relationship remains the core determinant of resectability throughout the preoperative and intraoperative periods.The application of surgical techniques including combined autologous small bowel transplantation and sub-adventitial divestment technique has also facilitated the development of curative resection,yet such procedures rely heavily on clinical experience from high-volume pancreatic centers.With the advancement of precision medicine and artificial intelligence,novel conversion regimens and evaluation systems will enable more precise identification of patients who can achieve long-term survival benefits from curative surgery,ultimately leading to sustained improvements in long-term survival.关键词
局部进展期胰腺癌/转化治疗/系统治疗/手术指征/预后Key words
locally advanced pancreatic cancer/conversion therapy/systemic therapy/surgical indication/prognosis分类
医药卫生引用本文复制引用
许静涌,朱昱,晏宇鹏,杨尹默..系统治疗背景下对胰腺癌手术指征再认识[J].中国实用外科杂志,2026,46(8):1042-1045,1049,5.基金项目
National Natural Science Foundation of China(No.82541012,No.82573693) 国家自然科学基金项目(No.82541012,No.82573693) （No.82541012,No.82573693）
