中国听力语言康复科学杂志2026，Vol.24Issue(5)：484-491,8.DOI:10.3969/j.issn.1672-4933.2026.05.007
基于婴幼儿有意义听觉整合量表建立并验证婴幼儿听损程度预测模型
Development and Validation of a Prediction Model for the Severity of Hearing Loss in Infant and Toddler Based on IT-MAIS
摘要
Abstract
Objective To establish and validate a multimodal prediction model for the degree of hearing loss in infants and young children based on the Infant-Toddler Meaningful Auditory Integration Scale(IT‑MAIS)in combination with objective audiological indicators and perinatal risk factors.Methods According to the screening criteria,553 infants aged 0‑6 months who had completed audiological diagnostic tests and the IT‑MAIS were enrolled.Based on the results of tone‑burst auditory brainstem response(ABR),the subjects were divided into three groups according to the degree of hearing loss as the outcome variable:normal‑mild,moderate,and severe.Risk factors affecting the degree of hearing loss were analyzed.Univariate and multivariate logistic regression were used to screen independent variables,establish the prediction model,and construct a nomogram.The discrimination of the model was assessed using the receiver operating characteristic(ROC)curve;calibration was verified by calibration plots;and clinical utility was explored by decision curve analysis(DCA).Results Seven predictive factors were screened to construct the model and form a nomogram,including advanced maternal age(P=0.004),family history of permanent childhood hearing loss(P=0.001),presence or suspicion of a syndrome or genetic disorder associated with hearing loss(P<0.001),distortion product otoacoustic emissions(P<0.001),and total IT‑MAIS score(P<0.001).After validation,the area under the curve for distinguishing moderate and above hearing loss and severe‑profound hearing loss was 0.904(95%CI:0.876‑0.932)and 0.954(95%CI:0.930‑0.978),respectively.Notable consistency was observed between the predicted probabilities and the actual probabilities,with mean absolute errors of 0.014 and 0.011.Within a certain range,the model had practical value in identifying populations at risk for different degrees of hearing loss.Conclusion The prediction model for the degree of hearing loss in infants and young children established in this study demonstrates acceptable discrimination,predictive ability,and clinical applicability,providing a scientific basis for the early identification of children with hearing loss and for promoting early detection and early intervention.关键词
婴幼儿有意义听觉整合量表/听力损失/婴幼儿/预测模型Key words
Infant-toddler meaningful auditory integration scale/Hearing loss/Infant and toddler/Prediction model分类
医药卫生引用本文复制引用
尹慧琳,顾海玲,李刚,孟照莉..基于婴幼儿有意义听觉整合量表建立并验证婴幼儿听损程度预测模型[J].中国听力语言康复科学杂志,2026,24(5):484-491,8.基金项目
四川省科学技术厅项目"2～6月龄中耳功能正常婴儿的宽频声导抗值特征初探"(2021YFS0220) （2021YFS0220）
