中国听力语言康复科学杂志2026，Vol.24Issue(5)：496-500,5.DOI:10.3969/j.issn.1672-4933.2026.05.009
咽喉反流与声带病变的相关性及其嗓音声学分析
The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice
摘要
Abstract
Objective To investigate the prevalence differences of laryngopharyngeal reflux(LPR)in different types of vocal cord lesions(chronic inflammation,benign lesions,precancerous lesions)and analyze the impact of LPR on acoustic function in patients with voice disorders.Methods A total of 533 patients with voice disorders were enrolled and classified into three groups based on clinical diagnosis:inflammatory group(n=222),benign group(including polyps,nodules,cysts,Riecked's edema,and granulomas,n=250),and precancerous group(vocal cord leukoplakia,n=61).LPR was assessed using the Reflux Symptom Index(RSI)and Reflux Finding Score(RFS).Acoustic parameters,including fundamental frequency(F0),Jitter,Shimmer,maximum phonation time(MPT),and dysphonia severity index(DSI),were recorded and analyzed using voice analysis software.Differences among groups and within LPR subgroups were compared.Results The overall prevalence of LPR was 50.09%(267/533),showing a significant increasing trend across the three groups:inflammatory group(36.94%,82/222),benign group(58.00%,145/250),and precancerous group(65.57%,40/61),with statistically significant differences(P<0.001).Acoustic analysis revealed that the Jitter and Shimmer in the benign and precancerous groups were significantly higher than those in the inflammatory group,while the DSI and MPT was significantly reduced(P<0.05).Subgroup analysis revealed that compared with non-LPR cases,LPR-positive individuals in the benign and precancerous groups exhibited more severe vocal impairment,with significantly reduced DSI in both groups.LPR-positive patients in the benign group showed increased Jitter and Shimmer,while those in the precancerous group exhibited elevated Jitter and Shimmer accompanied by reduced MPT,with statistically significant differences(P<0.05).Conclusion LPR is closely associated with the occurrence and progression of vocal cord lesions,with its prevalence markedly increasing as the lesion nature advances.Patients with vocal cord benign lesions and precancerous lesions demonstrate clear superimposed vocal function impairments,where LPR serves as a key controllable factor influencing vocal recovery prognosis.Therefore,all patients with vocal disorders should undergo LPR screening and acoustic vocal assessment follow-up.Targeted LPR evaluation and management should be implemented for patients with vocal cord benign and precancerous lesions to optimize vocal therapy outcomes.关键词
咽喉反流/声带良性病变/声带白斑/声学分析Key words
Laryngopharyngeal reflux/Vocal cord benign lesions/Vocal cord leukoplakia/Acoustic analysis分类
医药卫生引用本文复制引用
黄萌,陈文勇..咽喉反流与声带病变的相关性及其嗓音声学分析[J].中国听力语言康复科学杂志,2026,24(5):496-500,5.基金项目
国家中医药管理局高水平中医药重点学科建设项目"中医耳鼻喉科学"(zyyzdxk-2023163) （zyyzdxk-2023163）
广州市科技计划项目"基于'肠道微生物-肠-脑轴'理论探讨柴胡疏肝散治疗反流性咽喉疾病的疗效及作用机制研究"(2023B03J0301) （2023B03J0301）
广东省中医院中医药科学技术研究专项"'抑木扶土法'干预反流性咽喉疾病随机对照临床研究及肠道菌群影响的研究"(YN2020MS03) （YN2020MS03）
