中国药理学通报2026，Vol.42Issue(9)：1601-1606,6.DOI:10.12360/CPB202604051
从形态再生到功能重塑:缺血性脑卒中后血管修复研究进展
From morphological regeneration to functional remodeling:research advances in vascular repair after ischemic stroke
摘要
Abstract
The high disability rate following ischemic stroke(IS)is fundamentally attributed to impaired neurological re-pair.Consequently,the structural integrity and functional re-modeling of blood vessels act as essential prerequisites for estab-lishing a favorable microenvironment for neural regeneration.This review outlines the recent paradigm shift in post-stroke vas-cular repair from sheer"morphological regeneration"towards systemic"functional remodeling".Specifically,it elucidates the pathological mechanisms underlying microcirculatory disor-ders,such as the formation of neutrophil extracellular traps(NETs)and the imbalance of immune-vascular interactions,alongside the application of cutting-edge technologies like single-cell omics in microenvironment evaluation.Further-more,this review highlights emerging pharmacological interven-tions based on vascular normalization,engineered exosomes,and smart nanodelivery systems,aiming to provide novel in-sights into neurovascular unit protection and the development of innovative targeted therapeutics.关键词
缺血性脑卒中/血管重塑/血脑屏障/中性粒细胞胞外诱捕网/靶向递送/药理学干预Key words
ischemic stroke/vascular remodeling/blood-brain barrier/neutrophil extracellular traps/targeted delivery/pharmacological intervention分类
医药卫生引用本文复制引用
陈丽香,楚世峰,张钊..从形态再生到功能重塑:缺血性脑卒中后血管修复研究进展[J].中国药理学通报,2026,42(9):1601-1606,6.基金项目
国家自然科学基金资助项目(No 82374060) （No 82374060）
