中国药理学通报2026，Vol.42Issue(9)：1612-1619,8.DOI:10.12360/CPB202602057
巨噬细胞极化在肾纤维化中的作用与调控机制及中医药干预研究进展
Role and regulatory mechanisms of macrophage polarization in renal fibrosis and advances in traditional Chinese medicine intervention research
摘要
Abstract
Renal fibrosis(RF)is a common pathological fea-ture of chronic kidney disease progressing to end-stage renal dis-ease,mainly characterized by abnormal extracellular matrix(ECM)deposition,renal structural destruction and functional disorder.Imbalanced macrophage polarization acts as a key driving factor in this process.In the injured renal microenviron-ment,macrophages polarize into the M1 phenotype(pro-inflammatory)and the M2 phenotype(anti-inflammatory and pro-fibrotic).M1 macrophages initiate inflammation and induce early renal injury,while M2 macrophages mediate tissue repair and promote excessive ECM deposition.The imbalance between the two phenotypes continuously promotes the progression of RF.Multiple signaling pathways,including TGF-β/Smad,JAK/STAT and NF-κB,as well as metabolic reprogramming,epigen-etic regulation and gut microbiota dysbiosis,are involved in regulating macrophage polarization.With the advantages of multi-component and multi-target effects,traditional Chinese medicine(TCM)can regulate the M1/M2 balance by interven-ing in the above pathways through herbal monomers and com-pound prescriptions,thereby inhibiting inflammation and fibro-sis,showing promising therapeutic potential.This paper sys-tematically reviews the role of macrophage polarization in RF and its regulatory mechanisms and research advances in TCM intervention,so as to provide a theoretical basis and research ideas for TCM prevention and treatment of RF.关键词
肾纤维化/巨噬细胞极化/信号通路/代谢重编程/表观遗传修饰/中医药Key words
renal fibrosis/macrophage polarization/signaling pathways/metabolic reprogramming/epigenetic modification/traditional Chinese medicine分类
医药卫生引用本文复制引用
马晶瑜,王宝蕊,邵心韵,张雪娇,窦振国,尤婕,许赢,李建省..巨噬细胞极化在肾纤维化中的作用与调控机制及中医药干预研究进展[J].中国药理学通报,2026,42(9):1612-1619,8.基金项目
国家自然科学基金资助项目(No 82360884) （No 82360884）
