中国药理学通报2026，Vol.42Issue(9)：1620-1625,6.DOI:10.12360/CPB202603107
谷氨酰胺代谢与氨死亡:机制及治疗新策略
Glutamine metabolism and ammonia-induced cell death:mechanisms and novel therapeutic strategies
摘要
Abstract
Ammonia has traditionally been viewed as a toxic by-product of hepatic metabolism.However,the recent discovery of ammonia-induced cell death(AICD)-a distinct mode of regu-lated cell death-has challenged this dogma and unveiled new therapeutic opportunities in cancer immunotherapy.Herein,we delineate the molecular underpinnings of AICD and its meta-bolic interplay with glutamine metabolism,discuss glutamine-targeted anti-cancer strategies,and explore ammonia-metabo lism-directed combinatorial immunotherapy approaches.We further critically appraise the current obstacles and translational hurdles facing this nascent field.关键词
谷氨酰胺代谢/氨死亡/抗肿瘤/CD8+Teff细胞/耐药/免疫细胞Key words
glutamine metabolism/ammonia-induced cell death/antitumor/CD8+Teff cells/drug resistance/immune cells分类
医药卫生引用本文复制引用
秦晴艳,蔡诗坤,谭亲友..谷氨酰胺代谢与氨死亡:机制及治疗新策略[J].中国药理学通报,2026,42(9):1620-1625,6.基金项目
国家自然科学基金资助项目(No 82160765) （No 82160765）
广西自然科学基金资助项目(No 025JJA140834) （No 025JJA140834）
