中国针灸2026，Vol.46Issue(9)：1415-1420,6.DOI:10.13703/j.0255-2930.20250604-k0002
电针运动区治疗帕金森病伴骨骼肌肉疼痛的临床疗效及安全性观察
Clinical efficacy and safety of electroacupuncture at the motor area for Parkinson's disease with musculoskeletal pain:a randomized controlled trial
摘要
Abstract
Objective To observe the clinical efficacy and safety of electroacupuncture(EA)at the motor area for Parkinson's disease(PD)with musculoskeletal pain.Methods Fifty-eight patients with PD accompanied by musculoskeletal pain were randomly assigned to an EA group(29 cases,1 case dropped out)and a sham EA group(29 cases,1 case dropped out).The EA group was treated with EA at the motor area contralateral to the painful side(for bilateral pain,the left motor area was selected),using disperse-dense wave(2 Hz/20 Hz),with a current intensity of 1-2 mA,and needles were retained for 30 min.The sham EA group was treated with sham EA at non-acupoint area located 5-20 mm posterior to the motor area contralateral to the painful side.The connection mode was the same as that in the EA group,but no electrical current was delivered,and the needles were retained for 30 min.Both groups were treated once daily for 5 consecutive days.Visual analogue scale(VAS)for pain,unified Parkinson's disease rating scale part Ⅲ(UPDRS-Ⅲ),24-item Hamilton depression rating scale(HAMD-24),Hamilton anxiety rating scale(HAMA),and 39-item Parkinson's disease questionnaire(PDQ-39)scores were evaluated before treatment,immediately after treatment,and at 2 and 4 weeks after treatment completion in the two groups.Safety was also assessed in the two groups.Results In both groups,VAS scores for pain after treatment and at 2 and 4 weeks after treatment completion were lower than those before treatment(P＜0.01,P＜0.05).VAS scores for pain in the EA group were lower than those in the sham EA group after treatment and at 2 and 4 weeks after treatment completion(P＜0.05).In the EA group,UPDRS-Ⅲ,HAMD-24,HAMA,and PDQ-39 scores after treatment and at 2 and 4 weeks after treatment completion were lower than those before treatment(P＜0.05,P＜0.01).In the sham EA group,there were no statistically significant differences in UPDRS-Ⅲ,HAMD-24,HAMA,and PDQ-39 scores at any post-treatment time point compared with those before treatment(P＞0.05).There were no statistically significant differences in UPDRS-Ⅲ,HAMD-24,HAMA,and PDQ-39 scores between the two groups at any post-treatment time point(P＞0.05).No serious adverse events occurred during the trial.Conclusion EA at the motor area could reduce pain intensity in patients with PD accompanied by musculoskeletal pain,and improve pain-related motor symptoms,emotional status,and quality of life,with a favorable safety profile.关键词
帕金森病/骨骼肌肉疼痛/电针/运动区/视觉模拟量表评分/随机对照试验Key words
Parkinson's disease(PD)/musculoskeletal pain/electroacupuncture/motor area/visual analogue scale(VAS)score/randomized controlled trial(RCT)引用本文复制引用
朱四欢,夏阿龙,朱本藩,王安琴,谷好好,梅珊珊,陈怀珍,李俊..电针运动区治疗帕金森病伴骨骼肌肉疼痛的临床疗效及安全性观察[J].中国针灸,2026,46(9):1415-1420,6.基金项目
2021国家重点研发计划——重大慢性非传染性疾病防控研究重点专项:2021YFC2501200 （）
2021安徽省高校优秀拔尖人才培育资助项目:gxgwfx2021028 （）
2021安徽省高校科学研究项目:KJ2021A0568 （）
2021安徽中医药大学临床科研项目:2021yfylc06 （）
2022安徽省重点研究与开发计划项目:2022e07020025 （）
2022安徽省卫生健康科研项目:AHWJ2022b015 （）
2024安徽省高校科研计划:2024AH050998 （）
2024安徽省自然科学基金项目:2408085MH228 （）
